JNK1/2/3 Products

Description

JNKs (c-Jun N-terminal kinases) belong to a family of MAP kinases that are involved in a variety of cellular processes, including transcriptional regulation and cellular proliferation, differentiation and development. JNK2 (c-Jun Nterminal kinase 2) and JNK3 (c-Jun N-terminal kinase 3) are 424 and 464 amino acid proteins, respectively, that each contain one protein kinase domain and use magnesium as a cofactor to catalyze the phosphorylation of target proteins, thereby playing a role in a variety of events throughout the cell. Both JNK2 and JNK3 exist as multiple alternatively spliced isoforms and are subject to post-translational phosphorylation on Thr 183 and Thr 221, respectively, an event which activates JNK2/JNK3 enzymatic activity. Defects in the gene encoding JNK3 are a cause of epileptic encephalopathy of the Lennox-Gastaut type, a group of epileptic disorders characterized by severe psychomotor delay and seizures.

Bioinformatics

Entrez	116554 Rat 5599 Human 5602 Human
Uniprot	P45983 Human
Product By Gene ID	5599
Alternate Names	c-Jun N-terminal kinase 1 EC 2.7.11 EC 2.7.11.24 JNK1 alpha protein kinase JNK1 beta protein kinase JNK1JNK1A2 JNK-46 JUN N-terminal kinase MAP kinase 8 MAPK 8 mitogen-activated protein kinase 8 isoform JNK1 alpha1 mitogen-activated protein kinase 8 isoform JNK1 beta2 mitogen-activated protein kinase 8 PRKM8JNK protein kinase JNK1 SAPK1JNK21B1/2 Stress-activated protein kinase 1 Stress-activated protein kinase JNK1

Research Areas for JNK1/2/3

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Breast Cancer
Cancer
Cell Cycle and Replication
Diabetes Research
Hypoxia
MAP Kinase Signaling
Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway