PDCD6 Antibody (722232)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PDCD6 (Programmed cell death protein 6; also ALG-2 and apoptosis-linked gene 2 protein) is a 22 kDa member of the penta-EF hand protein family of molecules. It is ubiquitously expressed, and performs multiple functions. PDCD6 is contextually linked to apoptosis, proliferation, membrane fusion and vesicle trafficking. Human PDCD6 is 191 amino acids (aa) in length. Although it contains five EF-hand domains, only domains #1 and #3 are considered functional (aa 23-58 and 90‑125). There is one splice form (ALG-2.1) that shows a deletion of Gly121Phe122. This form typically represents about 1/3 of total cellular PDCD6. PDCD6/ALG-2 will homodimerize, and heterodimerize with ALG-2.1. Notably, there are classes of cytosolic proteins that bind PDCD6, but not ALG-2.1, accounting for differences in function. Both human PDCD6 isoforms share 99% aa identity with their mouse counterparts.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB6015	Applications	Species
Date, Y;Sasazawa, Y;Kitagawa, M;Gejima, K;Suzuki, A;Saya, H;Kida, Y;Imoto, M;Itakura, E;Hattori, N;Saiki, S; Novel autophagy inducers by accelerating lysosomal clustering against Parkinson's disease eLife 2024-07-03 [PMID: 38899618] (Western Blot, Human)	Western Blot	Human

Array MAB6015

• PDCD6 Antibodies
• PDCD6 ELISA Kits
• PDCD6 Lysate
• PDCD6 Protein