Parkin Antibody (1H4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 5 of 5.

Publications using H00005071-M01	Applications	Species
Tan HWS, Lu G, Dong H et al. A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery Nature communications 2022-06-28 [PMID: 35764633]
Chongkui Sun, Kun Wang, Amanda J Stock, Yi Gong, Tyler G Demarest, Beimeng Yang, Neelam Giri, Lea Harrington, Blanche P Alter, Sharon A Savage, Vilhelm A Bohr, Yie Liu Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction The EMBO Journal 2020-09-16 [PMID: 32935380]
Scuderi Soraya, La Cognata Valentina, Drago Filippo et al. Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain. Biomed Res Int. 2014-07-16 [PMID: 25136611]
La Cognata Valentina, Iemmolo Rosario, D'Agata Velia et al. Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. Curr Genomics. 2014-06-01 [PMID: 24955028]
Brody KM, Taylor JM, Wilson GR et al. Regional cellular localisation of Parkin Co-Regulated Gene in developing adult mouse brain. Brain Res 1201:177-86. 2008-03-27 [PMID: 18295750]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	09/26/2017	View Summary Application Western Blot Sample Tested Mouse skeletal muscle homogenate Species Mouse Lot H6011-1H4 Comments Comments Western Blot: Parkin Antibody (1H4) [H00005071-M01] - Western blot analysisi was performed in mouse skeletal muscle proteins, separated by 4-12% SDS-PAGE. Proteins were transferred on nitrocellulose membrane and blocked in 5% non-fat milk for 1h at room temperature. Anti Parkin antibody was used 1:1000
Enlarge	3 reviewed by: Verified Customer	Simple Western	Human	08/22/2016	View Summary Application Simple Western Sample Tested SVG-A cells (different total protein concentrations of the mitochondria-enriched fraction versus whole-cell lysate) Species Human

Array H00005071-M01

• Parkin Antibodies
• Parkin Lysate
• Parkin Proteins
• Parkin Proteins and Enzymes