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Pappalysin-1/PAPP-A Antibody (PAPP A1-24) [DyLight 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC
Clone
PAPP A1-24
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 594

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-05043AF350
Alexa Fluor 405
NBP1-05043AF405
Alexa Fluor 488
NBP1-05043AF488
Alexa Fluor 532
NBP1-05043AF532
Alexa Fluor 594
NBP1-05043AF594
Alexa Fluor 647
NBP1-05043AF647
Alexa Fluor 700
NBP1-05043AF700
Alexa Fluor 750
NBP1-05043AF750
Biotin
NBP1-05043B
CoraFluor 1
NBP1-05043CL1
DyLight 350
NBP1-05043UV
DyLight 405
NBP1-05043V
DyLight 488
NBP1-05043G
DyLight 550
NBP1-05043R
DyLight 650
NBP1-05043C
DyLight 680
NBP1-05043FR
DyLight 755
NBP1-05043IR
FITC
NBP1-05043F
HRP
NBP1-05043H
Janelia Fluor 525
NBP1-05043JF525
Janelia Fluor 549
NBP1-05043JF549
Janelia Fluor 585
NBP1-05043JF585
Janelia Fluor 635
NBP1-05043JF635
Janelia Fluor 646
NBP1-05043JF646
Janelia Fluor 669
NBP1-05043JF669
PerCP
NBP1-05043PCP
Unconjugated
NBP1-05043
mFluor Violet 450 SE
NBP1-05043MFV450
mFluor Violet 500 SE
NBP1-05043MFV500
mFluor Violet 610 SE
NBP1-05043MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-05043
BSA Free
NBP1-05043
BSA Free
NBP1-05043-0.025mg
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Pappalysin-1/PAPP-A Antibody (PAPP A1-24) [DyLight 594] Summary

Immunogen
Purified human PAPP-A
Epitope
The epitope is located on the PAPP-A subunit of the heterotetramer.
Specificity
specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
PAPPA
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Pappalysin-1/PAPP-A Antibody (PAPP A1-24) [DyLight 594]

  • ASBABP2
  • DIPLA1
  • EC 3.4.24.79
  • IGFBP-4ase
  • IGFBP-4aseaspecific BCL2 ARE-binding protein 2
  • IGF-dependent IGFBP-4 protease
  • insulin-like growth factor-dependent IGF binding protein-4 protease
  • Insulin-like growth factor-dependent IGF-binding protein 4 protease
  • PAPA
  • PAPPA
  • PAPPA1
  • PAPP-A1
  • PAPP-Adifferentially placenta 1 expressed protein
  • Pappalysin1
  • Pappalysin-1
  • pregnacy-associated plasma protein A
  • Pregnancy-associated plasma protein A
  • pregnancy-associated plasma protein A, pappalysin 1

Background

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Pappalysin-1/PAPP-A An ...
NBP1-05043DL594
Pappalysin-1/PAPP-A Antibody (PAPP A1-24) [DyLight 594]
Species: Hu
Applications: WB, ELISA, IHC

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FAQs for Pappalysin-1/PAPP-A Antibody (NBP1-05043DL594). (Showing 1 - 1 of 1 FAQ).

  1. I am highly interested to use couple of Anti-PAPP-A antibodies from your reputed companies for my research work. I have got the information regarding the immunogen used to generate these antibodies, however could not get any information regarding the specific amino acids/epitope to which your Anti-PAPP-A Antibodies binds with the antigen (PAPP-A).
    • Unfortunately, none of our PAPP A antibodies have been epitope mapped. Many of them have also been generated against full-length PAPP A, so there are many potential binding sites.

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Bioinformatics

Gene Symbol PAPPA