Pappalysin-1/PAPP-A Products

Description

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

Bioinformatics

Uniprot	NP_002572 Human NP_002572.2 Human Q13219 Human
Product By Gene ID	5069
Alternate Names	ASBABP2 DIPLA1 EC 3.4.24.79 IGFBP-4aseaspecific BCL2 ARE-binding protein 2 IGF-dependent IGFBP-4 protease insulin-like growth factor-dependent IGF binding protein-4 protease Insulin-like growth factor-dependent IGF-binding protein 4 protease PAPA PAPPA1 PAPP-Adifferentially placenta 1 expressed protein pappalysin-1 pregnacy-associated plasma protein A Pregnancy-associated plasma protein A pregnancy-associated plasma protein A, pappalysin 1

Research Areas for Pappalysin-1/PAPP-A

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