p70 S6 Kinase/S6K Antibody (215247) [Alexa Fluor® 488]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

p70 S6 Kinase (p70S6K) is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues. p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6K activity undergoes changes during the cell cycle and increases 20‑fold in G1 cells released from G0. p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well asT389, a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK1) (1-3). Over amino acids (aa) 1-502, human and mouse share 99% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array IC8962G

• p70 S6 Kinase/S6K Antibodies
• p70 S6 Kinase/S6K ELISA Kit
• p70 S6 Kinase/S6K Lysate
• p70 S6 Kinase/S6K Proteins
• p70 S6 Kinase/S6K ELISAs
• p70 S6 Kinase/S6K Proteins and Enzyme