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P2Y12/P2RY12 Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: P2Y12/P2RY12 Antibody [NBP1-89673] - Staining in human cerebral cortex and skeletal muscle tissues using NBP1-89673 antibody. Corresponding P2RY12 RNA-seq ...read more
Immunohistochemistry-Paraffin: P2Y12/P2RY12 Antibody [NBP1-89673] - Staining of human cerebellum shows strong positivity in microglia.
Immunohistochemistry-Paraffin: P2Y12/P2RY12 Antibody [NBP1-89673] - Staining of human cerebral cortex shows strong positivity in microglia.
Immunohistochemistry-Paraffin: P2Y12/P2RY12 Antibody [NBP1-89673] - Staining of human lung shows moderate to strong membranous positivity in macrophages.
Immunohistochemistry-Paraffin: P2Y12/P2RY12 Antibody [NBP1-89673] - Staining of human skeletal muscle shows no positivity in myocytes as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

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P2Y12/P2RY12 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: LTNRQPRDKNVKKCSFLKSEFGLVWHEIV
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
P2RY12
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
P2Y12/P2RY12 Protein (NBP1-89673PEP)
Publications
Read Publication using NBP1-89673.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (86%), Rat (83%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for P2Y12/P2RY12 Antibody

  • ADPG-R
  • Gi-coupled ADP receptor HORK3
  • HORK3
  • HORK3P2Y12 platelet ADP receptor
  • P2RY12
  • P2T(AC)
  • P2Y purinoceptor 12
  • P2Y(AC)
  • P2Y(ADP)
  • P2Y(cyc)
  • P2Y12
  • P2Y12ADP-glucose receptor
  • purinergic receptor P2RY12
  • purinergic receptor P2Y, G-protein coupled, 12
  • putative G-protein coupled receptor
  • SP1999
  • SP1999G-protein coupled receptor SP1999

Background

P2Y12 is a Purinergic Receptor essential for the aggregation of blood platelets. There is evidence that mutations in P2Y12 cause a bleeding disorder, suggesting that knowledge of the P2Y12 receptor could advance the development of antiplatelet agents to treat cardiovascular diseases. Expression of P2Y12 has been reported in platelets, spinal cord, and many brain regions. ESTs for P2Y12 have been isolated from B-cell/lung/testis, brain, embryo, prostate, eye, kidney carcinoma, and colon carcinoma libraries. Cognate

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for P2Y12/P2RY12 Antibody (NBP1-89673)(1)


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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol P2RY12