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N-Deacetylase/N-Sulfotransferase 1/NDST1 Antibody [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 646

Order Details

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N-Deacetylase/N-Sulfotransferase 1/NDST1 Antibody [Janelia Fluor® 646] Summary

Immunogen
NDST1 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human NDST1. Amino Acid Squence: SRFKYRTEIAPGKGDMPT
Specificity
N-Deacetylase/N-Sulfotransferase 1/NDST1 Antibody is predicted to not cross-react with NDST2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NDST1
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for N-Deacetylase/N-Sulfotransferase 1/NDST1 Antibody [Janelia Fluor® 646]

  • [Heparan sulfate]-glucosamine N-sulfotransferase 1
  • bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
  • EC 2.8.2.8
  • Glucosaminyl N-deacetylase/N-sulfotransferase 1
  • heparan sulfate-N-deacetylase/N-sulfotransferase
  • HSNST 1
  • HSNST1
  • HSST1
  • HSSTN-HSST 1
  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
  • NDST1
  • NDST-1
  • N-heparan sulfate sulfotransferase 1
  • NST1

Background

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backboneto make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a rolein determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence isabsolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands,thereby playing a role in inflammatory response

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NDST1