Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1 Antibody (738306)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Heparan sulfate is a highly sulfated polysaccharide found on the cell surface and within the extracellular matrix. Typically, it is covalently attached to the protein core of proteoglycans, such as syndecans and glypicans. Heparin, on the other hand, can be considered as a highly sulfated version of heparan sulfate that is predominantly found in mast cells. Both heparin and heparan sulfate contain disaccharide repeats of uronic acid and N‑acetylglucosamine and are modified by the same sulfotransferases (1, 2). The uronic acid residues are either glucuronic acid or iduronic acid and maybe sulfated at the 2-O position by heparan sulfate 2‑O sulfotransferase 1 (HS2ST1) (3, 4). HS2ST1 physically interacts in the Golgi apparatus with glucuronyl c5-epimerase (5), which catalyzes the conversion of glucuronic acid to iduronic acid (6). As a consequence, 2-O sulfation predominantly occurs on iduronic acids naturally and overexpression of HS2ST1 alone causes an increase in 2-O sulfation on glucuronic acid (7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB6335

• Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1 Antibodies
• Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1 ELISA Kits
• Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1 Lysate
• Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1 Proteins
• Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1 Proteins and Enzyme