Myocilin Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Myocilin (also known as TIGR) is a variably glycosylated, 65 kDa, secreted polypeptide that belongs to the family of olfactomedin-related proteins. Human Myocilin is synthesized as a 490 amino acid (aa) precursor that contains an 18 aa signal sequence, an 84 aa N-terminus, a 53 aa alpha -helical leucine zipper and a 335 aa C-terminus that contains a 260 aa OLF-domain. An alternate start site generates a signal-sequenceless 504 aa mature protein. Myocilin forms nondisulfide-linked dimers and multimers. The human 32 kDa OLF-domain shares 87% aa sequence identity with the OLF-domain in bovine, rat and mouse.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque), Transgenic Mouse.

We have publications tested in 2 applications: ICC, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF2537	Applications	Species
JM Lynch, AJ Dolman, C Guo, K Dolan, C Xiang, S Reda, B Li, G Prasanna Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle PLoS ONE, 2018-11-05;13(11):e0206801. 2018-11-05 [PMID: 30395621] (Western Blot, Human, Transgenic Mouse)	Western Blot	Human, Transgenic Mouse
JM Lynch, B Li, P Katoli, C Xiang, B Leehy, N Rangaswamy, V Saenz-Vash, YK Wang, H Lei, TB Nicholson, E Meredith, D Rice, G Prasanna, A Chen Binding of a glaucoma-associated myocilin variant to the ?B-crystallin chaperone impedes protein clearance in trabecular meshwork cells J. Biol. Chem., 2018-11-02;0(0):. 2018-11-02 [PMID: 30389787] (Western Blot, Human, Transgenic Mouse)	Western Blot	Human, Transgenic Mouse
Pfeffer BA, DeWitt CA, Salvador-Silva M, Cavet ME, Lopez FJ, Ward KW Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids. Invest. Ophthalmol. Vis. Sci., 2009-08-20;51(1):437-46. 2009-08-20 [PMID: 19696178] (Western Blot, Primate - Macaca mulatta (Rhesus Macaque))	Western Blot	Primate - Macaca mulatta (Rhesus Macaque)
Schlunck G, Han H, Wecker T, Kampik D, Meyer-ter-Vehn T, Grehn F Substrate rigidity modulates cell matrix interactions and protein expression in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci., 2008-01-01;49(1):262-9. 2008-01-01 [PMID: 18172101] (ICC, Human)	ICC	Human

Array AF2537

• Myocilin Antibodies
• Myocilin ELISA Kits
• Myocilin Lysate
• Myocilin Proteins
• Myocilin Proteins and Enzyme