MuRF1/TRIM63 Antibody

MURF1 encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 8 of 8.

Publications using NB100-2406	Applications	Species
Wang Z, Sa G, Wei Z et al. Obvious morphologic changes in the mandible and condylar cartilage after triple botulinum toxin injections into the bilateral masseter American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2020-10-01 [PMID: 32988574] (IF/IHC, Rat)	IF/IHC	Rat
Mota R, Rodriguez JE, Bonetto A et al. Post-translationally modified muscle-specific ubiquitin ligases as circulating biomarkers in experimental cancer cachexia. Am J Cancer Res. 2017-10-05 [PMID: 28979816] (WB, Mouse) Details: Used to detect circulating MuRF1 in diluted mouse serum samples by western blot following implantation of tumors	WB	Mouse
Opperman CM, Sishi BJ. Tumor necrosis factor alpha stimulates p62 accumulation and enhances proteasome activity independently of ROS Cell Biol. Toxicol. 2015-03-12 [PMID: 25761618] (WB, Rat) Details: MuRF1/TRIM63 antibody (Imgenex: IMX-3924) was used for WB assay on lysates of H9C2 rat cardiomyoblast cell line following daily treatment with TNF-alpha. Signal detection was performed using peroxidase-conjugated affinity-purified anti-goat IgG and ECL method (Fig. 6).	WB	Rat
Dumont NA, Frenette J. Macrophage Colony-Stimulating Factor-Induced Macrophage Differentiation Promotes Regrowth in Atrophied Skeletal Muscles and C2C12 Myotubes Am J Pathol 2012-11-27 [PMID: 23201131]
Penet M-F, Gadiya MM, Krishnamachary B et al. Metabolic signatures imaged in cancer-induced cachexia. Cancer Research. 2011-09-26 [PMID: 21948967]
Marioni G, Staffieri A, Giacomelli L et al. Mammalian target of rapamycin expression and laryngeal squamous cell carcinoma prognosis: novel preliminary evidence. Histopathology;58(7):1148-1156. 2011-06-01 [PMID: 21707714] (IF/IHC, Human)	IF/IHC	Human
Willis MS, Rojas M, Li L et al. Muscle Ring Finger-1 (MuRF1) Mediates Cardiac Atrophy in vivo. Am J Physiol Heart Circ Physiol 2009-04-01 [PMID: 19168726]
Cao PR, Kim HJ, Lecker SH. Ubiquitin-protein ligases in muscle wasting. Int J Biochem Cell Biol 2005-10-01 [PMID: 16125112]

Array NB100-2406

• MuRF1/TRIM63 Antibodies
• MuRF1/TRIM63 Proteins