Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Mouse TIM-1/KIM-1/HAVCR DuoSet ELISA, 15 Plate
CD365
HAVCR1
HAVCR-1
HAVCRT cell immunoglobin domain and mucin domain protein 1
hepatitis A virus cellular receptor 1
Kidney injury molecule 1
KIM1
KIM-1
T-cell immunoglobulin and mucin domain-containing protein 1
TIM1
TIM-1
TIM-1TIM
TIM1TIMD-1
TIMD1T-cell membrane protein 1
Background
TIM-1 (T cell immunoglobulin and mucin domain 1), also known as KIM-1 and HAVcr1, is expressed on many immune cell types and epithelial cells. It binds to phosphatidylserine (PS), LMIR5/CD300b, TIM-1 (homophilic), TIM-4, IgA, and the glycoproteins of a number of enveloped viruses. Its interaction with PS enables TIM-1 to mediate the phagocytosis and clearance of apoptotic cells. TIM-1 signaling costimulates T cell activation and enhances Th2 cytokine production. TIM-1 serves as a cellular entry receptor for hepatitis A virus, Ebolavirus and Marburgvirus. Polymorphisms are associated with susceptibility to atopy, autoimmunity, and severe hepatitis A virus infection in humans. A soluble form of TIM-1 is elevated in the urine during nephropathy.