Mouse IL-2 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-2 (Interleukin 2) is a critical cytokine in T cell biology. It promotes T cell activation and expansion, the development, maintenance and function of regulatory T cells (Treg), and the differentiation of CD8+ T cells into terminal effector cells and memory cells. IL-2 signals through a receptor complex composed of CD25/IL-2 R alpha, IL-2 R beta, and the Common gamma Chain (gamma c). IL-2 R beta is also a component of the IL-15 receptor complex. Gamma c is also a signaling subunit in the receptors for IL-4, -7, -9, -15, and -21.

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 56. Show All 56 Publications. Collapse Publications.

Publications using M2000	Applications	Species
Mehta, NK;Rakhra, K;Meetze, KA;Li, B;Momin, N;Chang, JY;Wittrup, KD;Baeuerle, PA;Michaelson, JS; CLN-617 retains IL-2 and IL-12 in injected tumors to drive robust and systemic immune-mediated antitumor activity Cancer immunology research 2024-06-06 [PMID: 38842347] (Mouse)		Mouse
Cheng, H;Ji, Z;Wang, Y;Li, S;Tang, T;Wang, F;Peng, C;Wu, X;Cheng, Y;Liu, Z;Ma, M;Wang, J;Huang, X;Wang, L;Qin, L;Liu, H;Chen, J;Zheng, R;Feng, CG;Cai, X;Qu, D;Ye, L;Yang, H;Ge, B; Mycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice Nature microbiology 2024-05-28 [PMID: 38806671] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
Qiu, Z;Khalife, J;Lin, AP;Ethiraj, P;Jaafar, C;Chiou, L;Huelgas-Morales, G;Aslam, S;Arya, S;Gupta, YK;Dahia, PLM;Aguiar, RCT; IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes bioRxiv : the preprint server for biology 2023-10-15 [PMID: 37873241] (Mouse)		Mouse
You, Y;Kim, SH;Kim, CH;Kim, IH;Shin, Y;Kim, TR;Sohn, M;Park, J; Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide Microorganisms 2023-09-13 [PMID: 37764156] (Mouse)		Mouse
Ni, J;Guo, T;Zhou, Y;Jiang, S;Zhang, L;Zhu, Z; STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury Journal of translational medicine 2023-09-04 [PMID: 37667317] (Mouse)		Mouse
M Drouin, J Saenz, V Gauttier, B Evrard, G Teppaz, S Pengam, C Mary, A Desselle, V Thepenier, E Wilhelm, E Merieau, C Ligeron, I Girault, MD Lopez, C Fourgeux, D Sinha, I Baccelli, A Moreau, C Louvet, R Josien, J Poschmann, N Poirier, E Chiffoleau CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy Science Advances, 2022-11-18;8(46):eabo7621. 2022-11-18 [PMID: 36399563] (Mouse)		Mouse
L Dayani, MS Dinani, M Aliomrani, H Hashempour, J Varshosaz, A Taheri Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis Oncogene, 2022-06-10;64(0):103958. 2022-06-10 [PMID: 35716476] (Mouse)		Mouse
JD Hathaway-S, JD Aartun, NA Poulides, MB Kuhn, BE McCormick, ME Chew, E Huang, RP Darveau, C Westwater, CM Novince Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 35077397] (Mouse)		Mouse
H Zhang, S Ge, B Ni, K He, P Zhu, X Wu, Y Shao Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages Autophagy, 2021-05-04;0(0):. 2021-05-04 [PMID: 33849389] (Mouse)		Mouse
F Wang, B Chau, SM West, CR Kimberlin, F Cao, F Schwarz, B Aguilar, M Han, W Morishige, C Bee, G Dollinger, A Rajpal, P Strop Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions Nature Communications, 2021-03-02;12(1):1378. 2021-03-02 [PMID: 33654081] (Mouse)		Mouse
MR Charan Raj, A Kar, S Srinivasan, D Chellappan, J Debnath, S Kar Mahapa Oral administration of eugenol oleate cures experimental visceral leishmaniasis through cytokines abundance Cytokine, 2020-10-28;0(0):155301. 2020-10-28 [PMID: 33127258] (Mouse)		Mouse
C Focaccetti, M Benvenuto, S Ciuffa, S Fazi, M Scimeca, A Nardi, MT Miele, A Battisti, E Bonanno, A Modesti, L Masuelli, R Bei Curcumin Enhances the Antitumoral Effect Induced by the Recombinant Vaccinia Neu Vaccine (rV-neuT) in Mice with Transplanted Salivary Gland Carcinoma Cells Nutrients, 2020-05-14;12(5):. 2020-05-14 [PMID: 32423101] (Mouse)		Mouse
R Wang, K Huang CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL?2 and TGF?&beta by CD4+ T�cells via the STAT5 signaling pathway Mol Med Rep, 2020-04-01;0(0):. 2020-04-01 [PMID: 32323817] (Mouse)		Mouse
S Esaki, F Goshima, H Ozaki, G Takano, Y Hatano, D Kawakita, K Ijichi, T Watanabe, Y Sato, T Murata, H Iwata, Y Shibamoto, S Murakami, Y Nishiyama, H Kimura Oncolytic activity of HF10 in head and neck squamous cell carcinomas Cancer Gene Ther., 2019-09-03;0(0):. 2019-09-03 [PMID: 31477804] (Mouse)		Mouse
HH Guo, CL Feng, WX Zhang, ZG Luo, HJ Zhang, TT Zhang, C Ma, Y Zhan, R Li, S Wu, Z Abliz, C Li, XL Li, XL Ma, LL Wang, WS Zheng, YX Han, JD Jiang Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases Nat Commun, 2019-04-30;10(1):1981. 2019-04-30 [PMID: 31040273] (Mouse)		Mouse
BG Lania, J Morari, AR Almeida, MND Silva, G Vieira-Dam, KA Lins, CL César, LA Velloso, NB Maia, ML Cintra, PENF Velho Topical essential fatty acid oil on wounds: Local and systemic effects PLoS ONE, 2019-01-04;14(1):e0210059. 2019-01-04 [PMID: 30608959] (Mouse)		Mouse
HM Song, X Li, YY Liu, WP Lu, ZH Cui, L Zhou, D Yao, HM Zhang Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS Int. J. Mol. Med., 2018-03-27;0(0):. 2018-03-27 [PMID: 29620148] (Mouse)		Mouse
Q Jiang, X He, Y Zou, Y Ding, H Li, H Chen Altered gut microbiome promotes proteinuria in mice induced by Adriamycin AMB Express, 2018-02-28;8(1):31. 2018-02-28 [PMID: 29492783] (Mouse)		Mouse
V Vetvicka, J Vetvickova Glucans and Cancer: Comparison of Commercially Available ?-glucans - Part IV Anticancer Res., 2018-03-01;38(3):1327-1333. 2018-03-01 [PMID: 29491056] (Mouse)		Mouse
FM Iseka, BT Goetz, I Mushtaq, W An, LR Cypher, TA Bielecki, EC Tom, P Arya, S Bhattachar, MD Storck, CL Semerad, JE Talmadge, RL Mosley, V Band, H Band Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function J. Immunol., 2017-12-06;0(0):. 2017-12-06 [PMID: 29212907] (Mouse)		Mouse
H Yang, HZ Guo, XY Li, J Lin, W Zhang, JM Zhao, HX Zhang, SJ Chen, Z Chen, J Zhu Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance J. Immunol., 2017-05-26;0(0):. 2017-05-26 [PMID: 28550197] (Mouse)		Mouse
SJ Whitfield, C Taylor, JE Risdall, GD Griffiths, JT Jones, ED Williamson, S Rijpkema, L Saraiva, S Vessillier, AC Green, AJ Carter Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology J. Immunol, 2017-03-20;0(0):. 2017-03-20 [PMID: 28320831] (Mouse)		Mouse
D Fujikura, M Ikesue, T Endo, S Chiba, H Higashi, T Uede Death receptor 6 contributes to autoimmunity in lupus-prone mice Nat Commun, 2017-01-03;8(0):13957. 2017-01-03 [PMID: 28045014] (Mouse)		Mouse
Yong Zhan Anti-tumor effects of (1?3)-?-d-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice Int. J. Biol. Macromol., 2016-11-09;0(0):. 2016-11-09 [PMID: 27838421] (Mouse)		Mouse
Ji-Hua Chen Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration Biomaterials, 2016-10-31;113(0):203-216. 2016-10-31 [PMID: 27821306] (Mouse)		Mouse
Bolz M, Kerber S, Zimmer G, Pluschke G Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. PLoS Negl Trop Dis, 2015-08-14;9(8):e0004011. 2015-08-14 [PMID: 26275222] (Mouse)		Mouse
Shvedova A, Kisin E, Yanamala N, Tkach A, Gutkin D, Star A, Shurin G, Kagan V, Shurin M MDSC and TGFbeta Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes. Cancer Res, 2015-03-05;75(8):1615-23. 2015-03-05 [PMID: 25744719] (Mouse)		Mouse
Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol, 2015-02-02;16(3):286-95. 2015-02-02 [PMID: 25642823] (Mouse)		Mouse
Annamanedi M, Kalle A Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. PLoS ONE, 2014-06-20;9(6):e99285. 2014-06-20 [PMID: 24950067] (Mouse)		Mouse
Yamane , Kazuhiko, Indalao , Irene L, Chida , Junji, Yamamoto , Yoshikaz, Hanawa , Masaaki, Kido , Hiroshi Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza. PLoS ONE, 2014-05-27;9(5):e98032. 2014-05-27 [PMID: 24865588] (Mouse)		Mouse
D'Souza , Alain J, Desai , Shyamal, Rudner , Xiaowen, Kelly , Michelle, Ruan , SanBao, Shellito , Judd E Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. PLoS ONE, 2013-02-25;8(2):e56890. 2013-02-25 [PMID: 23451104] (Mouse)		Mouse
Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes. J. Immunol., 2012-09-19;189(9):4237-46. 2012-09-19 [PMID: 22993203] (Mouse)		Mouse
Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. J. Biol. Chem., 2012-03-23;287(20):16356-64. 2012-03-23 [PMID: 22447930] (Mouse)		Mouse
Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, Zhou Y, Wang H, Shen B, Zhang X Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system. PLoS ONE, 2011-09-13;6(9):e24751. 2011-09-13 [PMID: 21931843] (Mouse)		Mouse
Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference. Immunol. Lett., 2011-01-26;136(2):194-202. 2011-01-26 [PMID: 21277900] (Mouse)		Mouse
Liu J, Ngai N, Stone GW, Yue FY, Ostrowski MA The adjuvancy of OX40 ligand (CD252) on an HIV-1 canarypox vaccine. Vaccine, 2009-06-30;27(37):5077-84. 2009-06-30 [PMID: 19573639] (Mouse)		Mouse
Kim W, Fan YY, Smith R, Patil B, Jayaprakasha GK, McMurray DN, Chapkin RS Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. J. Nutr., 2009-03-25;139(5):1042-8. 2009-03-25 [PMID: 19321585] (Mouse)		Mouse
Sofra V, Mansour S, Liu M, Gao B, Primpidou E, Wang P, Li S Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection. Eur. J. Immunol., 2009-01-01;39(1):85-95. 2009-01-01 [PMID: 19089809] (Mouse)		Mouse
Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response. Vaccine, 2008-06-12;26(33):4237-43. 2008-06-12 [PMID: 18584925] (Mouse)		Mouse
Besin G, Gaudreau S, Menard M, Guindi C, Dupuis G, Amrani A Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes. Diabetes, 2008-05-13;57(8):2107-17. 2008-05-13 [PMID: 18477807] (Mouse)		Mouse
Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses. Eur. J. Immunol., 2008-05-01;38(5):1358-67. 2008-05-01 [PMID: 18425727] (Mouse)		Mouse
Lau AW, Biester S, Cornall RJ, Forrester JV Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells. J. Immunol., 2008-03-15;180(6):3889-99. 2008-03-15 [PMID: 18322197] (Mouse)		Mouse
Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation. J. Immunol., 2007-09-15;179(6):3742-51. 2007-09-15 [PMID: 17785811] (Mouse)		Mouse
Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells. J. Immunol., 2007-09-15;179(6):3638-47. 2007-09-15 [PMID: 17785799] (Mouse)		Mouse
Ke Y, Sun D, Zhang P, Jiang G, Kaplan HJ, Shao H Suppression of established experimental autoimmune uveitis by anti-LFA-1alpha Ab. Invest. Ophthalmol. Vis. Sci., 2007-06-01;48(6):2667-75. 2007-06-01 [PMID: 17525198] (Mouse)		Mouse
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet., 2007-02-04;39(3):329-37. 2007-02-04 [PMID: 17277778] (Mouse)		Mouse
Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis. J. Immunol., 2007-01-15;178(2):851-7. 2007-01-15 [PMID: 17202346] (Mouse)		Mouse
McCubbin MD, Hou G, Abrams GD, Dick R, Brewer GJ Tetrathiomolybdate is effective in a mouse model of arthritis. J. Rheumatol., 2006-10-15;33(12):2501-6. 2006-10-15 [PMID: 17143984] (Mouse)		Mouse
Zhang Q, Yang XJ, Kundu SD, Pins M, Javonovic B, Meyer R, Kim SJ, Greenberg NM, Kuzel T, Meagher R, Guo Y, Lee C Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle. Mol. Cancer Ther., 2006-07-01;5(7):1733-43. 2006-07-01 [PMID: 16891459] (Mouse)		Mouse
Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Mouse)		Mouse
Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schafer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes. Blood, 2006-03-02;107(12):4841-8. 2006-03-02 [PMID: 16514061] (Mouse)		Mouse
Yu G, Luo H, Wu Y, Wu J EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J. Biol. Chem., 2004-10-22;279(53):55531-9. 2004-10-22 [PMID: 15502157] (Mouse)		Mouse
Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Comp. Immunol. Microbiol. Infect. Dis., 2004-11-01;27(6):393-411. 2004-11-01 [PMID: 15325513] (Mouse)		Mouse
Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J. Neurosci., 2004-07-07;24(27):6133-43. 2004-07-07 [PMID: 15240805] (Mouse)		Mouse
Oka H, Emori Y, Sasaki H, Shiraishi Y, Yoshinaga K, Kurimoto T Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis. Microbiol. Immunol., 2002-01-01;46(5):343-51. 2002-01-01 [PMID: 12139394]
Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol., 2001-07-01;31(7):2104-15. 2001-07-01 [PMID: 11449364] (Mouse)		Mouse
Show All 56 Publications. Collapse Publications.

Array M2000

• IL-2 Antibodies
• IL-2 ELISA Kits
• IL-2 Kit
• IL-2 Lysate
• IL-2 Proteins
• IL-2 Proteins and Enzymes
• IL-2 ELISAs