MHC Class I Antibody (MEM-E/08) [PE]

The antigenic agglomerate major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8-positive T cells. It is now recognized that the products of the MHC genes are antigen-presenting molecules (APM) designed for the presentation of antigen fragments (peptides) to the T-cell receptor, thus participating in the immune response (1). Recently shown is a mechanism of antigen acquisition for cross-presentation that couples the antigen presentation system of two adjacent cells and is lost in most tumours: gap-junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen presenting cells for cross-priming (2). The mammalian vomeronasal organ detects social information about gender, status, and individuality. It has been shown that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor-expressing zone of the vomeronasal epithelium (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Greta Beckerle	Flow	Human	11/15/2017	View Summary Application Flow Cytometry Sample Tested HIV-infected CD4 T cells Species Human Lot 526800-101217-P Comments Comments Antibody used to measure changes in HLA-E expression on HIV-infected cells, which could influence efficacy of effector cells that recognise HIV via HLA-E.

Array NB500-305PE

• MHC Class I Antibodies
• MHC Class I Lysate