mGluR6 Antibody

Metabotropic Glutamate Receptor 6 (Mglur6 or Grm6), member of class III of Mglur family/GPCR3 family, is a multi-pass membrane protein localized in cell membrane with restricted expression in retinal inner nuclear layer on dendrites of ON-bipolar cells wherein it interact with effector G protein G0 alpha and act as a receptor for glutamate. An increment of light intensity in retina hyperpolarizes the photoreceptor to set off two opposing signals in OFF and ON bipolar cells, whereas in darkness, glutamate released by photoreceptors depolarizes OFF bipolar cells with hyperpolarization of ON bipolar cells. This ON bipolar cell "sign inverting" cascade involves glutamate mediated activation of Mglur6 leading to G0 alpha stimulation which results in closure of a presumably constitutively active nonselective cation channel TRPM1 (transient receptor potential melastatin 1). mGluR6 activity is mediated by a G-protein that inhibits adenylate cyclase activity and mGluR6 is the only known mGluR that mediates direct synaptic transmission in the nervous system with its role in mediating ON-response in vertebrate retinal ON-pathway. Genetic inactivation of mGluR6 in murine model blocks the ON-response and in humans, mutations in the mGluR6 gene have been linked to congenital stationary night blindness, characterized in the electroretinogram by the absence of an ON response.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-Fr, WB.

Showing Publications 1 - 6 of 6.

Publications using NB300-189	Applications	Species
Elisabetta Catalani, Silvia Bongiorni, Anna Rita Taddei, Marta Mezzetti, Federica Silvestri, Marco Coazzoli, Silvia Zecchini, Matteo Giovarelli, Cristiana Perrotta, Clara De Palma, Emilio Clementi, Marcello Ceci, Giorgio Prantera, Davide Cervia Defects of full-length dystrophin trigger retinal neuron damage and synapse alterations by disrupting functional autophagy Cellular and Molecular Life Sciences 2020-08-04 [PMID: 32749504]
Fan Y, Lai J, Yuan Y et al. Taurine Protects Retinal Cells and Improves Synaptic Connections in Early Diabetic Rats Curr. Eye Res. 2020-01-01 [PMID: 31404506]
Yang, Y, Liu, W Et al. Tmem30a deficiency leads to retinal rod bipolar cell degeneration. J Neurochem 2019-02-01 [PMID: 30548540] (WB, Human)	WB	Human
Toya S, Takatsuru Y, Kokubo M et al. Early-life-stress affects the homeostasis of glutamatergic synapses. Eur J Neurosci. 2014-09-13 [PMID: 25220177]
Gu L, Liang X, Wang L, Yan Y, Ni Z, Dai H, Gao J, Mou S, Wang Q, Chen X, Wang L, Qian J. Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes. Kidney Int;81(5):458-68. 2012-03-01 [PMID: 22166849] (WB, IHC-Fr, Mouse)	WB, IHC-Fr	Mouse
Takada Y, Vijayasarathy C, Zeng Y, Kjellstrom S, Bush RA, Sieving PA. Synaptic pathology in retinoschisis knockout (Rs1-/y) mouse retina and modification by rAAV-Rs1 gene delivery. Invest Ophthalmol Vis Sci;49(8):3677-86. 2008-08-01 [PMID: 18660429] (IHC-Fr, Mouse)	IHC-Fr	Mouse

Array NB300-189

• mGluR6 Antibodies
• mGluR6 Lysate
• mGluR6 Proteins