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MDR1/ABCB1 Antibody (OTI1A7) [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, Rt, GtSpecies Glossary
Applications IHC, ICC/IF
Clone
OTI1A7
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-72607AF350
Alexa Fluor 405
NBP2-72607AF405
Alexa Fluor 488
NBP2-72607AF488
Alexa Fluor 532
NBP2-72607AF532
Alexa Fluor 594
NBP2-72607AF594
Alexa Fluor 647
NBP2-72607AF647
Alexa Fluor 700
NBP2-72607AF700
Alexa Fluor 750
NBP2-72607AF750
CoraFluor 1
NBP2-72607CL1
DyLight 350
NBP2-72607UV
DyLight 405
NBP2-72607V
DyLight 488
NBP2-72607G
DyLight 550
NBP2-72607R
DyLight 594
NBP2-72607DL594
DyLight 650
NBP2-72607C
DyLight 680
NBP2-72607FR
DyLight 755
NBP2-72607IR
FITC
NBP2-72607F
HRP
NBP2-72607H
Janelia Fluor 525
NBP2-72607JF525
Janelia Fluor 549
NBP2-72607JF549
Janelia Fluor 585
NBP2-72607JF585
Janelia Fluor 635
NBP2-72607JF635
Janelia Fluor 646
NBP2-72607JF646
Janelia Fluor 669
NBP2-72607JF669
Unconjugated
NBP2-46466
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-46466
Azide and BSA Free
NBP2-72607
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MDR1/ABCB1 Antibody (OTI1A7) [Biotin] Summary

Immunogen
Recombinant protein fragment corresponding to amino acids 995-1280 of human MDR1/ABCB1 (NP_000918) produced in SF9 cell.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
ABCB1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for MDR1/ABCB1 Antibody (OTI1A7) [Biotin]

  • ABC20
  • ABCB1
  • ABCB1B
  • ATP-binding cassette sub-family B member 1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • CD243 antigen
  • CD243
  • CLCS
  • colchicin sensitivity
  • doxorubicin resistance
  • EC 3.6.3
  • EC 3.6.3.44
  • GP170
  • IBD13
  • MDR1
  • MDR1MGC163296
  • multidrug resistance protein 1
  • P-glycoprotein 1
  • P-gp
  • PGY1
  • PGY1P-GP

Background

MDR1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ABCB1