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MDR1/ABCB1 Antibody (MRK16) [PerCP]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, IP, CyTOF-ready
Clone
MRK16
Clonality
Monoclonal
Host
Mouse
Conjugate
PerCP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-52701AF350
Alexa Fluor 405
NBP2-52701AF405
Alexa Fluor 488
NBP2-52701AF488
Alexa Fluor 532
NBP2-52701AF532
Alexa Fluor 594
NBP2-52701AF594
Alexa Fluor 647
NBP2-52701AF647
Alexa Fluor 700
NBP2-52701AF700
Alexa Fluor 750
NBP2-52701AF750
Allophycocyanin
NBP2-52701APC
DyLight 350
NBP2-52701UV
DyLight 405
NBP2-52701V
DyLight 488
NBP2-52701G
DyLight 550
NBP2-52701R
DyLight 594
NBP2-52701DL594
DyLight 650
NBP2-52701C
DyLight 680
NBP2-52701FR
DyLight 755
NBP2-52701IR
FITC
NBP2-52701F
Janelia Fluor 549
NBP2-52701JF549
Janelia Fluor 646
NBP2-52701JF646
PE
NBP2-52701PE
Unconjugated
NBP2-52701-0.1mg
mFluor Violet 450 SE
NBP2-52701MFV450
mFluor Violet 500 SE
NBP2-52701MFV500
mFluor Violet 610 SE
NBP2-52701MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-52701-0.1mg
Azide and BSA Free
NBP2-52701-0.1mg
Azide and BSA Free
NBP2-52701-0.025mg
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MDR1/ABCB1 Antibody (MRK16) [PerCP] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Drug resistant K-562 cells.
Specificity
Recognizes a discontinuous extracellular epitope on P-glycoprotein.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ABCB1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for MDR1/ABCB1 Antibody (MRK16) [PerCP]

  • ABC20
  • ABCB1
  • ABCB1B
  • ATP-binding cassette sub-family B member 1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • CD243 antigen
  • CD243
  • CLCS
  • colchicin sensitivity
  • doxorubicin resistance
  • EC 3.6.3
  • EC 3.6.3.44
  • GP170
  • IBD13
  • MDR1
  • MDR1MGC163296
  • multidrug resistance protein 1
  • P-glycoprotein 1
  • P-gp
  • PGY1
  • PGY1P-GP

Background

MDR1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ABCB1