Matriptase/ST14 Antibody

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using NB100-2308	Applications	Species
Wadhawan V, Kolhe YA, Sangith N et al. From prediction to experimental validation: desmoglein 2 is a functionally relevant substrate of matriptase in epithelial cells and their reciprocal relationship is important for cell adhesion. Biochem J 2012-10-01 [PMID: 22783993]
Welman A, Sproul D, Mullen P et al. Diversity of matriptase expression level and function in breast cancer. PLoS One 2012-01-01 [PMID: 22514623]
Xu H, Xu Z, Tseng IC et al. Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. Am J Physiol Cell Physiol 2012-01-01 [PMID: 22031598]
Desilets A, Beliveau F, Vandal G et al. Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease. J Biol Chem 2008-04-01 [PMID: 18263585]
Mildner M, Ballaun C, Stichenwirth M et al. Gene silencing in a human organotypic skin model. Biochem Biophys Res Commun 2006-09-01 [PMID: 16875670]
Desilets A, Longpre JM, Beaulieu ME et al. Inhibition of human matriptase by eglin c variants. FEBS Lett 2006-04-01 [PMID: 16566926]

Array NB100-2308

• Matriptase/ST14 Antibodies
• Matriptase/ST14 Lysate
• Matriptase/ST14 Protein
• Matriptase/ST14 Proteins and Enzymes
• Matriptase/ST14 ELISA