MARCKS [p Ser152, p Ser156] Antibody

Myristolated Alanine-Rich C-Kinase Substrate (MARCKS) is a major in vivo substrate of protein kinase C (PKC) and for the lipid-activated PKC-related kinase (PRK1). Furthermore, PRK1 and OPKC phosphorylate MARCKS on the same sites in vitro, serine 152, 156, and 163. MARCKS serves as an in vitro substrate for PKCu as well. However, in contrast to other PKCs, MARCKS is phosphorylated by PKCu only at serine 156 and not at serines 152 and 163, implicating a differential regulation by PKCu. Therefore, control of MARCKS phosphorylation on these previously identified 'PKC' sites may be regulated under certain circumstances by PRK as well as PKC mediated signaling pathways. MARCKS associates with the plasma membrane in response to PKC-catalyzed phosphorylation of MARCKS. It has been suggested that MARCKS is capable of associating with the plasma membrane through binding to phospholipids without interaction with membranous proteins.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Canine, Chinese Hamster.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NB500-140	Applications	Species
Pelletier G, Padhi BK, Hawari J et al. Development of a sensitive in vitro assay to quantify the biological activity of pro-inflammatory phorbol esters in Jatropha oil In Vitro Cell. Dev. Biol. Anim. 2015-01-15 [PMID: 25588777] (WB, Canine)	WB	Canine
Zhan, Y, Ahme, A M, McFarlane N,et al. Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways, . J Lipid Res. 2007 Feb;48(2):405-16. 2007-01-01 [PMID: 17079793] (WB, Chinese Hamster)	WB	Chinese Hamster

Array NB500-140

• MARCKS Antibodies
• MARCKS ELISA Kits
• MARCKS Proteins