MALT1 Antibody

MALT1/Paracaspase (MALT1) was independently identified as a member of the human procaspase family and an interacting partner of B-cell lymphoma (Uren et al., 2000). MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10 to activate NF-kappaB. MALT1 is thought to play an important role in NF-kappaB signaling by enhancing NF-kappaB activation through interaction with Bcl10 (Ho et al., 2005). Interaction between MALT1 and Bcl10 mediates IKK activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin-conjugating enzyme UBC13. Four recurrent chromosomal translocations have been described in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid issue (MALT) type. Two of them, t(14;18)(q32;q21) and t(11;18)(q21;q21), are found in 30% to 50% of extranodal MALT lymphomas. The first translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in the deregulation of MALT1 expression, whereas the second translocation generates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1). The other two much rarer translocations, t(1;14)(p22;q32)and t(1;2)(p22;p12), target Bcl10 gene on the short arm of chromosome 1. Translocations involving Bcl10 and MALT1 may lead to elevated NF-kappaB activity in MALT B-cell lymphoma. Two alternatively spliced transcript variants encoding different isoforms (a and b) have been described for the MALT1 gene. Human MALT1 isoform a is an amino acid protein of 824 amino acids, and human MALT1 isoform b is an amino acid protein of 813 amino acids.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB100-56158

• MALT1 Antibodies
• MALT1 Lysates
• MALT1 Proteins