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MAdCAM-1 Antibody (OTI1A5) [Janelia Fluor® 669]

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Product Details

Summary
Reactivity Hu, PoSpecies Glossary
Applications WB, ICC/IF
Clone
OTI1A5
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 669

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-72568AF350
Alexa Fluor 405
NBP2-72568AF405
Alexa Fluor 488
NBP2-72568AF488
Alexa Fluor 532
NBP2-72568AF532
Alexa Fluor 594
NBP2-72568AF594
Alexa Fluor 647
NBP2-72568AF647
Alexa Fluor 700
NBP2-72568AF700
Alexa Fluor 750
NBP2-72568AF750
Allophycocyanin
NBP2-72568APC
Biotin
NBP2-72568B
CoraFluor 1
NBP2-72568CL1
DyLight 350
NBP2-72568UV
DyLight 405
NBP2-72568V
DyLight 488
NBP2-72568G
DyLight 550
NBP2-72568R
DyLight 594
NBP2-72568DL594
DyLight 650
NBP2-72568C
DyLight 680
NBP2-72568FR
DyLight 755
NBP2-72568IR
FITC
NBP2-72568F
HRP
NBP2-72568H
Janelia Fluor 525
NBP2-72568JF525
Janelia Fluor 549
NBP2-72568JF549
Janelia Fluor 585
NBP2-72568JF585
Janelia Fluor 635
NBP2-72568JF635
Janelia Fluor 646
NBP2-72568JF646
PE
NBP2-72568PE
PerCP
NBP2-72568PCP
Unconjugated
NBP2-45706
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-45706
Azide and BSA Free
NBP2-72568
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MAdCAM-1 Antibody (OTI1A5) [Janelia Fluor® 669] Summary

Immunogen
Full length human recombinant protein of human MADCAM1(NP_570116) produced in HEK293T cell.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
MADCAM1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for MAdCAM-1 Antibody (OTI1A5) [Janelia Fluor® 669]

  • hMAdCAM-1
  • MACAM1
  • MAdCAM1
  • MAdCAM-1
  • mucosal addressin cell adhesion molecule 1
  • mucosal addressin cell adhesion molecule-1
  • mucosal vascular addressin cell adhesion molecule 1

Background

Mucosal vascular addressin-1 (MAdCAM-1) is a type I transmembrane glycoprotein expressed at high levels on high endothelial venules (HEV) of Peyer's patches and mesenteric lymph nodes, and on flat walled venules within the gut lamina propria. It is also expressed on sinus-lining cells in the spleen. (1-3) The countereceptor or "homing receptor" for MAdCAM-1 is alpha4beta7 integrin (also known as LPAM-1). MAdCAM-1 is also a facultative ligand for CD62L/L-selectin. (4, 5) The monoclonal antibody MECA-367 binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer's patch HEV in vivo. (1, 2, 4)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MADCAM1