Western Blot: Lumican Antibody [NBP1-87726] - Validation of extracellular matrix proteins differentially expressed in CNV patients. Representative Western blot images cropped from different gels with different exposure. ...read more
Immunohistochemistry-Paraffin: Lumican Antibody [NBP1-87726] - Staining of human breast shows moderate to strong cytoplasmic positivity.
Immunohistochemistry-Paraffin: Lumican Antibody [NBP1-87726] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: Lumican Antibody [NBP1-87726] - Staining of human skin shows moderate to strong cytoplasmic positivity in dermal cells.
This antibody was developed against Recombinant Protein corresponding to amino acids: DFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTF
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LUM
Purity
Immunogen affinity purified
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Mouse reactivity reported in scientific literature (PMID: 31582785). Rat (89%).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Lumican Antibody
KSPG lumican
LDC
LUM
lumican proteoglycan
Lumican
SLRR2D
SLRR2DLDCKeratan sulfate proteoglycan lumican
Background
Lumican encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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