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LRP5/6 Antibody

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Western Blot: LRP5/6 Antibody [NBP1-45687] - Analysis of LRP-5/6 with Jurkat cell lysate. Lane 1: 100 ug; Lane 2: 50 ug.
Western Blot: LRP5/6 Antibody [NBP1-45687] - Analysis of LRP-5/6 with Jurkat cell lysate. Lane 1: 100 ug; Lane 2: 50 ug.

Product Details

Summary
Product Discontinued
View other related LRP5/6 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-45687
    • Availability
      Product Discontinued

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LRP5/6 Antibody Summary

Immunogen
Synthetic peptide surrounding amino acid 437 of human LRP.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LRP5
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 - 4 ug/mL

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS, 0.5% BSA, 30% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.5 mg/ml
Purity
Affinity purified

Alternate Names for LRP5/6 Antibody

  • BMND1OPTA1
  • EVR1
  • EVR4
  • HBM
  • low density lipoprotein receptor-related protein 5
  • low density lipoprotein receptor-related protein 7
  • low-density lipoprotein receptor-related protein 5
  • LR3VBCH2
  • LRP-5
  • LRP7exudative vitreoretinopathy 1
  • OPPG
  • OPS
  • osteoporosis pseudoglioma syndrome

Background

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading to Axin degradation and beta catenin stabilization.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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Secondary Antibodies

 

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Research Areas for LRP5/6 Antibody (NBP1-45687)

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Blogs on LRP5/6.

Check out the latest blog posts on LRP5/6.
The role of Wnts in neuroinflammation
By Michalina Hanzel, PhDThe multifaceted roles of the Wnt family of glycoproteins have been extensively characterized throughout embryonic development and adult homeostasis. The highly conserved, cell- and tissue- s...  Read full blog post.
Read our latest blog and use the new citation tool on bio-techne.com

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Bioinformatics

Gene Symbol LRP5
Entrez
Uniprot