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LRH-1/NR5A2 Antibody (K8801)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
K8801
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Suitable Sample Type
23015

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LRH-1/NR5A2 Antibody (K8801) Summary

Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
NR5A2
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunoprecipitation

Packaging, Storage & Formulations

Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Buffer
A liquid formulation in physiologic saline with 0.1% NaN3.
Preservative
0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LRH-1/NR5A2 Antibody (K8801)

  • Alpha-1-fetoprotein transcription factor
  • B1-binding factor
  • b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus
  • B1F
  • B1F2
  • fetoprotein-alpha 1 (AFP) transcription factor
  • FTFLRH1
  • FTZ-F1 beta
  • FTZ-F1
  • FTZ-F1beta
  • HB1F
  • hB1F-2
  • hB1FCYP7A promoter-binding factor
  • Hepatocytic transcription factor
  • Liver receptor homolog 1
  • liver receptor homolog-1
  • LRH1
  • LRH-1
  • LRH-1CPF
  • NR5A2
  • nuclear receptor NR5A2
  • nuclear receptor subfamily 5 group A member 2
  • nuclear receptor subfamily 5, group A, member 2

Background

Liver receptor homolog-1 (LRH-1, FTF, CPF, hB1F, FTZ-F1b; NR5A2) is a member of the orphan nuclear receptor family. LRH-1 is a mammalian homolog of the Drosophila fushi tarazu Factor 1 gene product. LRH-1 is thought to be critical for development because LRH-1 knockout mice are not viable. LRH-1 is expressed in the liver, intestine, pancrease, ovary and preadipocytes.

LRH-1 is involved in the regulation of genes which participate in steroid, bile acid and cholesterol homeostasis. A role for LRH-1 in steroidogenesis is supported by its expression in ovarian granulosa cells and corpus luteum. LRH-1 has been shown to regulate transcription of several steroidogenic genes and is known to modulate the expression of aromatase in breast adipose tissue.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Bioinformatics

Gene Symbol NR5A2