LRH-1/NR5A2 Products

Description

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

Bioinformatics

Uniprot	NP_003813 Human NP_003813.1 Human NP_995582 Human O00482 Human
Product By Gene ID	2494
Alternate Names	Alpha-1-fetoprotein transcription factor B1-binding factor b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus B1F B1F2 fetoprotein-alpha 1 (AFP) transcription factor FTFLRH1 FTZ-F1 FTZ-F1beta HB1F hB1F-2 hB1FCYP7A promoter-binding factor Hepatocytic transcription factor Liver receptor homolog 1 liver receptor homolog-1 LRH-1CPF nuclear receptor NR5A2 nuclear receptor subfamily 5 group A member 2 nuclear receptor subfamily 5, group A, member 2

Research Areas for LRH-1/NR5A2

Find related products by research area and learn more about each of the different research areas below.

Chromatin Research
Neuroscience