LIGHT/TNFSF14 Antibody (115520) [Allophycocyanin]

Human LIGHT, also known as TNFSF14, is a type II membrane protein that is a member of the TNF superfamily. LIGHT is an acronym which stands for "is homologous to Lymphotoxins, exhibits Inducible expression, and competes with HSV Glycoprotein D for HVEM, a receptor expressed by T lymphocytes". LIGHT has also been called HVEM-L and LT-gamma . LIGHT is a 240 amino acid (aa) protein that contains a 37 aa cytoplasmic domain, a 22 aa transmembrane region, and a 181 aa extracellular domain. Similar to other TNF ligand family members, LIGHT is predicted to assemble as a homotrimer. LIGHT is produced by activated T cells and was first identified by its ability to compete with HSV glycoprotein D for HVEM binding. LIGHT has also been shown to bind to the Lymphotoxin beta Receptor (LT beta R) and the decoy receptor, DcR3/TR6. LIGHT overexpression in tumor cells induces apoptosis, which can be enhanced by IFN-gamma .

• LIGHT/TNFSF14 Antibodies
• LIGHT/TNFSF14 Lysate
• LIGHT/TNFSF14 Proteins
• LIGHT/TNFSF14 Proteins and Enzymes
• LIGHT/TNFSF14 ELISAs