LIF Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. The activities of LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ELISA Development.

Showing Publications 1 - 2 of 2.

Publications using BAF449	Applications	Species
Tsuyoshi Tsukada, Eriko Simamura, Hiroki Shimada, Takuma Arai, Nobuaki Higashi, Takuya Akai et al. The Suppression of Maternal–Fetal Leukemia Inhibitory Factor Signal Relay Pathway by Maternal Immune Activation Impairs Brain Development in Mice PLOS ONE 2015-06-04 [PMID: 26043040]
Moidunny S, Vinet J Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity. J Neuroinflammation, 2012-08-16;9(1):198. 2012-08-16 [PMID: 22894638] (ELISA Development, Mouse)	ELISA Development	Mouse

Array BAF449

• LIF Antibodies
• LIF ELISA Kit
• LIF Lysate
• LIF Proteins
• LIF Proteins and Enzymes
• LIF ELISAs