Langerin/CD207 Antibody (929F3.01) [Alexa Fluor® 546]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, EqSpecies Glossary
Applications Flow, ICC/IF, IHC
Clone
929F3.01
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 546

Order Details

Langerin/CD207 Antibody (929F3.01) [Alexa Fluor® 546] Summary

Immunogen
Langerin/CD207 was used as immunogen.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
CD207
Purity
Ion exchange chromatography
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000
  • Immunohistochemistry
Application Notes
Permeabilization is recommended for flow cytometry.

Packaging, Storage & Formulations

Storage
Store at -20C in the dark. Avoid freeze-thaw cycles.
Buffer
PBS and 50% Glycerol
Preservative
No Preservative
Purity
Ion exchange chromatography

Notes

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

This product is provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com.

Alternate Names for Langerin/CD207 Antibody (929F3.01) [Alexa Fluor® 546]

  • CD207 antigen
  • CD207 antigen, langerin
  • CD207 molecule, langerin
  • CD207
  • CLEC4KLangerhans cell specific c-type lectin
  • C-type lectin domain family 4 member K
  • C-type lectin domain family 4, member K
  • Langerin

Background

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Langerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CD207