KDM2A/FBXL11 Antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Block/Neutralize, Chemotaxis, KD, WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-74602	Applications	Species
Chen JK, Merrick KA, Kong YW et al. An RNA damage response network mediates the lethality of 5-FU in colorectal cancer. Cell reports. Medicine 2024-10-16 [PMID: 39378883]
Chen JK, Merrick KA, Kong YW et al. An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types bioRxiv : the preprint server for biology 2023-04-29 [PMID: 37162991] (Block/Neutralize)	Block/Neutralize
D’Amore C, Borgo C, Bosello Travain V, Salvi M KDM2A and KDM3B as Potential Targets for the Rescue of F508del-CFTR International Journal of Molecular Sciences 2022-08-25 [PMID: 36077010] (WB, KD, Human)	WB, KD	Human
Lu B, Wei J, Zhou H et al. Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3 Cell death & disease 2022-06-13 [PMID: 35697678] (Chemotaxis, Human)	Chemotaxis	Human
Ou R, Zhu L, Zhao L et al. HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway J. Cell. Physiol. 2018-08-21 [PMID: 30132864] (Chemotaxis, Human)	Chemotaxis	Human
Dhar Shilpa S, Alam Hunain, Li Na et al. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. J Biol Chem. 2014-03-14 [PMID: 24482232]
Wagner KW, Alam H, Dhar SS et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest 2013-12-02 [PMID: 24200691] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Hunain Alam	ICC	Human	10/08/2015	View Summary Application Immunocytochemistry Sample Tested Human lung tumor Species Human Lot A1
Enlarge	5 reviewed by: Hunain Alam	WB	Human	10/08/2015	View Summary Application Western Blot Sample Tested Lung cell lines whole cell lysate Species Human Lot A1

Array NB100-74602

• KDM2A/FBXL11 Antibodies
• KDM2A/FBXL11 Protein