IP3R1 Antibody

Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. Type-I IP3R has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II protein is found predominantly in the brain. Isoform III expression has been shown to occur in pancreatic islets, kidney and the gastrointestinal tract.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC/IF, WB, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using NB120-5908	Applications	Species
Ahmed M. O. Elbatsh, Ali Amin-Mansour, Anne Haberkorn, Claudia Textor, Nicolas Ebel, Emilie Renard, Lisa M. Koch, Femke C. Groenveld, Michelle Piquet, Ulrike Naumann, David A. Ruddy, Vincent Romanet, Julia M. Martínez Gómez, Matthew D. Shirley, Peter Wipfli, Christian Schnell, Markus Wartmann, Martin Rausch, Martine J. Jager, Mitchell P. Levesque, Sauveur-Michel Maira, Eusebio Manchado INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas Nature Cancer 2024-01-17 [PMID: 38233483]
Rojas ML, Muñoz JP, Flores-Martín J et al. StarD7 deficiency switches on glycolysis and promotes mitophagy flux in C2C12 myoblasts The FEBS journal 2023-10-16 [PMID: 37846201]
Del Bondio, A;Longo, F;De Ritis, D;Spirito, E;Podini, P;Brais, B;Bachi, A;Quattrini, A;Maltecca, F; Restoring calcium homeostasis in Purkinje cells arrests neurodegeneration and neuroinflammation in the ARSACS mouse model JCI insight 2023-05-09 [PMID: 37159335] (Western Blot, Mouse)	Western Blot	Mouse
Bononi A, Giorgi C, Patergnani S et al. BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation. Nature. 2017-06-22 [PMID: 28614305] (ICC/IF)	ICC/IF
Cabral WA, Ishikawa M, Garten M et al. Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta. PLoS Genet 2016-07-01 [PMID: 27441836]
Harr MW, McColl KS, Zhong F et al. Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes Autophagy 2010-10-01 [PMID: 20814235] (WB, Mouse)	WB	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	11/17/2010	View Summary Application Western Blot Sample Tested Jurkat whole cell lysate, primary CLL cells from human blood, Sample Amount: 80ug Species Human

Array NB120-5908

• IP3R1 Antibodies
• IP3R1 Proteins