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ILT4/CD85d/LILRB2 Antibody (287219R) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, B/N, CyTOF-ready
Clone
287219R
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

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ILT4/CD85d/LILRB2 Antibody (287219R) [Janelia Fluor® 646] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human LILRB2/CD85d/ILT4
Gly24-His458
Accession # ACT64556
Specificity
Detects human LILRB2/CD85d/ILT4 in direct ELISAs.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified from cell culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Neutralization
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from cell culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ILT4/CD85d/LILRB2 Antibody (287219R) [Janelia Fluor® 646]

  • CD85 antigen-like family member D
  • CD85d antigen
  • CD85d
  • Ig-like transcript 4
  • ILT4
  • ILT-4
  • ILT4CD85d
  • Immunoglobulin-like transcript 4
  • Leukocyte immunoglobulin-like receptor 2
  • leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform
  • leukocyte immunoglobulin-like receptor subfamily B member 2
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains)
  • LILRB2
  • LIR2
  • LIR2CD85D
  • LIR-2subfamily A (with TM domain), member 6
  • member 2
  • MIR10
  • MIR10LILRA6
  • Monocyte/macrophage immunoglobulin-like receptor 10

Background

LILRB2, also known as Leukocyte immunoglobulin-like receptor subfamily B member 2, has 2 isoforms, a 598 amino acid isoform that is 65 kDa and a 597 amino acid isoform that is approx. 65 kDa; expressed on monocytes and B-cells, and at lower levels on dendritic cells and in natural killer (NK) cells; as a receptor binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response; also competes with CD8A for binding to class I MHC antigens and inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Disease research is currently being performed with relation to LILRB2 and herpes simplex, chronic lymphocytic leukemia, lymphocytic leukemia, and leukemia. Interactions with this protein have been shown to involve PTPN6, FCGR1A, HLA-F, HLA-G, CD1D and other proteins in osteoclast differentiation, immune-regulatory interactions between a lymphoid and a non-lymphoid cell, adaptive immune system, and immune system pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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