IL-6 Antibody (6708) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length expressed as a 22-28 kDA molecular weight protein. IL-6 shares 39% aa sequence identity with mouse and rat IL-6. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor. IL-6, along with TNF-alpha and IL-1, function to drive the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, N/A.

We have publications tested in 14 applications: Affinity Chromatography, Antibody Array Development, Array Development, B/N, ELISA Capture, ELISA Development, ELISA Development (Capture), Electrochemiluminescent Assay, Flow Cytometry, ICC, IHC, IHC-Fr, Immunoassay Development, Neutralization.

Showing Publications 1 - 10 of 110. Show All 110 Publications. Collapse Publications.

Publications using MAB206	Applications	Species
Hong, J;Son, M;Sin, J;Kim, H;Chung, DK; Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation Nutrients 2023-11-09 [PMID: 38004123] (ELISA Capture, Human)	ELISA Capture	Human
Chi-An Cheng, Li-Chiao Chiang, Yu-Syuan Chu Integrated pipeline for ultrasensitive protein detection in cancer nanomedicine† RSC Advances 5/9/2023 [PMID: 37197682]
Lip Ket Chin, Jun-Yeong Yang, Benjamin Chousterman, Sunghoon Jung, Do-Geun Kim, Dong-Ho Kim et al. Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection ACS Nano 2/28/2023 [PMID: 36745820]
A Barron, S Manna, CJ McElwain, A Musumeci, FP McCarthy, GW O'Keeffe, CM McCarthy Maternal pre-eclampsia serum increases neurite growth and mitochondrial function through a potential IL-6-dependent mechanism in differentiated SH-SY5Y cells Frontiers in Physiology, 2023-01-12;13(0):1043481. 2023-01-12 [PMID: 36714304] (Neutralization, Human)	Neutralization	Human
M Tayyab, P Xie, MA Sami, H Raji, Z Lin, Z Meng, SR Mahmoodi, M Javanmard A portable analog front-end system for label-free sensing of proteins using nanowell array impedance sensors Scientific Reports, 2022-11-22;12(1):20119. 2022-11-22 [PMID: 36418852] (ELISA Capture, Human)	ELISA Capture	Human
W Singhatana, S Kitpakorns, M Toso, P Pavasant IFNgamma-primed periodontal ligament cells regulate T-cell responses via IFNgamma-inducible mediators and ICAM-1-mediated direct cell contact Royal Society open science, 2022-07-27;9(7):220056. 2022-07-27 [PMID: 35911203] (Neutralization, Human)	Neutralization	Human
Ce Zhang, Yuan Han, Xiaojun Liu, Hong Tan, Yuanlin Dong, Yiying Zhang et al. Odor Enrichment Attenuates the Anesthesia/Surgery-induced Cognitive Impairment Annals of Surgery 6/1/2023 [PMID: 35848747]
V Saxena, W Piao, L Li, C Paluskievi, Y Xiong, T Simon, R Lakhan, CC Brinkman, S Walden, KL Hippen, M WillsonShi, YS Lee, C Wagner, BR Blazar, JS Bromberg Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses Cell Reports, 2022-04-19;39(3):110727. 2022-04-19 [PMID: 35443187] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
B Zhong, B Cheng, X Huang, Q Xiao, Z Niu, YF Chen, Q Yu, W Wang, XJ Wu Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling Cell Death & Disease, 2021-12-20;13(1):16. 2021-12-20 [PMID: 34930899] (Neutralization, Human)	Neutralization	Human
Mohammad Rahbar, Yuling Wu, J. Anand Subramony, Guozhen Liu Sensitive Colorimetric Detection of Interleukin-6 via Lateral Flow Assay Incorporated Silver Amplification Method Frontiers in Bioengineering and Biotechnology 11/26/2021 [PMID: 34900966]
Lotta Wik, Niklas Nordberg, John Broberg, Johan Björkesten, Erika Assarsson, Sara Henriksson et al. Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis Molecular & Cellular Proteomics 10/27/2021 [PMID: 34715355]
Marina Chan, Siddharth Vijay, John McNevin, M Juliana McElrath, Eric C Holland, Taranjit S Gujral Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release Molecular Systems Biology 9/6/2021 [PMID: 34486798]
L Qin, X Cao, T Kaneko, C Voss, X Liu, G Wang, SS Li Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors The Journal of Biological Chemistry, 2021-09-02;0(0):101161. 2021-09-02 [PMID: 34480897] (Neutralization, Human)	Neutralization	Human
Xu Wang, David R. Walt Simultaneous detection of small molecules, proteins and microRNAs using single molecule arrays† Chemical Science 7/8/2020 [PMID: 34094160]
Takako Araki, Jutarat Sangtian, Darin Ruanpeng, Ramachandra Tummala, Brent Clark, Lynn Burmeister et al. Acute elevation of interleukin 6 and matrix metalloproteinase 9 during the onset of pituitary apoplexy in Cushing’s disease Pituitary 12/1/2021 [PMID: 34041660]
S Kamada, T Namekawa, K Ikeda, T Suzuki, M Kagawa, H Takeshita, A Yano, K Okamoto, T Ichikawa, K Horie-Inou, S Kawakami, S Inoue Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma Oncogene, 2021-05-10;0(0):. 2021-05-10 [PMID: 33972682] (IHC, Human)	IHC	Human
M Zheng, H Li, L Sun, DR Brigstock, R Gao Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-&beta1/Smad pathway Cytokine, 2021-04-21;0(0):155536. 2021-04-21 [PMID: 33893003] (Neutralization, Human)	Neutralization	Human
T Seki, N Yanaihara, JS Shapiro, M Saito, J Tabata, R Yokomizo, D Noguchi, T Kuroda, A Kawabata, J Suzuki, K Takahashi, H Matsuzawa, M Miyake, M Takenaka, Y Iida, S Yanagida, A Okamoto Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma Scientific Reports, 2021-04-08;11(1):7689. 2021-04-08 [PMID: 33833265] (Neutralization, Human)	Neutralization	Human
K Bernau, JP Leet, H Floerke, EM Bruhn, AL Noll, IS McDermott, S Esnault, NN Jarjour, N Sandbo Interleukin-1&alpha Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation Cells, 2021-03-02;10(3):. 2021-03-02 [PMID: 33801398] (ELISA Capture, Human)	ELISA Capture	Human
Fatemeh Khodadadei, Allen P. Liu, Carolyn A. Harris A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure Communications Biology 3/23/2021 [PMID: 33758339]
Zhan‐Wen Liang, Xin‐Xin Ge, Meng‐Dan Xu, Hualong Qin, Meng‐Yao Wu, Meng Shen et al. Tumor‐associated macrophages promote the metastasis and growth of non‐small‐cell lung cancer cells through NF‐ kappa B/PP2Ac‐positive feedback loop Cancer Science 6/1/2021 [PMID: 33609307]
Martina Kunkl, Carola Amormino, Simone Frascolla, Manolo Sambucci, Marco De Bardi, Silvana Caristi et al. CD28 Autonomous Signaling Orchestrates IL-22 Expression and IL-22-Regulated Epithelial Barrier Functions in Human T Lymphocytes Frontiers in Immunology 10/14/2020 [PMID: 33178223]
L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity Sci Rep, 2020-10-15;10(1):17444. 2020-10-15 [PMID: 33060625] (ELISA Capture, Human)	ELISA Capture	Human
MB Ware, MY Zaidi, J Yang, MK Turgeon, A Krasinskas, TA Mace, K Keenan, MR Farren, AN Ruggieri, Y Li, C Zhang, Z Chen, GS Young, O Elnaggar, Z Che, SK Maithel, T Bekaii-Saa, B El-Rayes, GB Lesinski Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease Br. J. Cancer, 2020-08-04;0(0):. 2020-08-04 [PMID: 32747748] (Neutralization, Human)	Neutralization	Human
T Pan, F Zhang, F Li, X Gao, Z Li, X Li, X Ren Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL?6/STAT3 signaling pathway Oncol. Rep., 2020-07-09;44(3):1049-1063. 2020-07-09 [PMID: 32705271] (B/N, Neutralization, Human)	B/N, Neutralization	Human
Valentin Haug, Branislav Kollar, Sotirios Tasigiorgos, Yori Endo, Martin Kauke, Ali-Farid Safi et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours Transplantation 9/1/2020 [PMID: 32168040]
Subrata Chowdhury, Logan Schulz, Biagio Palmisano, Parminder Singh, Julian M. Berger, Vijay K. Yadav et al. Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts Journal of Clinical Investigation 4/27/2020 [PMID: 32078586]
JS Hook, M Cao, K Weng, N Kinnare, JG Moreland Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4 J. Immunol., 2019-12-23;0(0):. 2019-12-23 [PMID: 31871022] (ELISA Capture, Human)	ELISA Capture	Human
X Sun, Q Qu, Y Lao, M Zhang, X Yin, H Zhu, Y Wang, J Yang, J Yi, M Hao Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer BMC Cancer, 2019-12-03;19(1):1180. 2019-12-03 [PMID: 31795965] (ELISA Capture, Human)	ELISA Capture	Human
A Stumpf, T Brandstett, J Hübner, J Rühe Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum PLoS ONE, 2019-12-02;14(12):e0225525. 2019-12-02 [PMID: 31790441] (ELISA Capture, Human)	ELISA Capture	Human
Gaohua Han, Kaijin Lu, Wansong Xu, Sihui Zhang, Junxing Huang, Chunlei Dai et al. Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury Oncology Letters 5/6/2019 [PMID: 31289503]
Martina Kunkl, Marta Mastrogiovanni, Nicla Porciello, Silvana Caristi, Emanuele Monteleone, Stefano Arcieri et al. CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-kappa B and STAT3 Transcription Factors on the Proximal Promoter Frontiers in Immunology 4/24/2019 [PMID: 31068940]
Purusottam Mohapatra, Chandra Prakash Prasad, Tommy Andersson Combination therapy targeting the elevated interleukin‐6 level reduces invasive migration of BRAF inhibitor‐resistant melanoma cells Molecular Oncology 2/1/2019 [PMID: 30582770]
J Hooda, M Novak, MP Salomon, C Matsuba, RI Ramos, E MacDuffie, M Song, MS Hirsch, J Lester, V Parkash, BY Karlan, M Oren, DS Hoon, R Drapkin Early loss of Histone H2B monoubiquitylation alters chromatin accessibility and activates key immune pathways that facilitate progression of ovarian cancer Cancer Res., 2018-12-18;0(0):. 2018-12-18 [PMID: 30563893] (Neutralization, Human)	Neutralization	Human
K Kuranda, P Jean-Alpho, C Leborgne, R Hardet, F Collaud, S Marmier, H Costa Verd, G Ronzitti, P Veron, F Mingozzi Exposure to wild-type AAV drives distinct capsid immunity profiles in humans J. Clin. Invest., 2018-10-22;0(0):. 2018-10-22 [PMID: 30352429] (Neutralization, Human)	Neutralization	Human
LL Niu, CL Cheng, MY Li, SL Yang, BG Hu, CCN Chong, SL Chan, J Ren, GG Chen, PBS Lai ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib Cell Death Dis, 2018-08-28;9(9):852. 8/28/2018 [PMID: 30154433]
SE Logue, EP McGrath, P Cleary, S Greene, K Mnich, A Almanza, E Chevet, RM Dwyer, A Oommen, P Legembre, F Godey, EC Madden, B Leuzzi, J Obacz, Q Zeng, JB Patterson, R Jäger, AM Gorman, A Samali Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy Nat Commun, 2018-08-15;9(1):3267. 2018-08-15 [PMID: 30111846] (Neutralization, Human)	Neutralization	Human
C Rolvering, AD Zimmer, A Ginolhac, C Margue, M Kirchmeyer, F Servais, HM Hermanns, S Hergovits, PV Nazarov, N Nicot, S Kreis, S Haan, I Behrmann, C Haan The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by ?-PD-L1 or ?-IL6 antibodies J. Leukoc. Biol., 2018-07-24;0(0):. 2018-07-24 [PMID: 30040142] (Neutralization, Human)	Neutralization	Human
B Gril, AN Paranjape, S Woditschka, E Hua, EL Dolan, J Hanson, X Wu, W Kloc, E Izycka-Swi, R Duchnowska, R P?ksa, W Biernat, J Jassem, N Nayyar, PK Brastianos, OM Hall, CJ Peer, WD Figg, GT Pauly, C Robinson, S Difilippan, E Bialecki, P Metellus, JP Schneider, PS Steeg Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases Psychoneuroendocrinology, 2018-07-13;9(1):2705. 2018-07-13 [PMID: 30006619] (Neutralization, Human)	Neutralization	Human
H Xu, Y Zhou, W Li, B Zhang, H Zhang, S Zhao, P Zheng, H Wu, J Yang Tumor-derived mesenchymal-stem-cell-secreted IL-6 enhances resistance to cisplatin via the STAT3 pathway in breast cancer Oncol Lett, 2018-04-11;15(6):9142-9150. 4/11/2018 [PMID: 29844821]
Mingjing Shen, Yongbing Chen, Lijun Xu, Rongying Zhu, Xiang Xue, Ying Tsai et al. Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells International Journal of Oncology 5/4/2018 [PMID: 29750425]
Jie Ji, Swapna Upadhyay, Xiaomiao Xiong, Maria Malmlöf, Thomas Sandström, Per Gerde et al. Multi-cellular human bronchial models exposed to diesel exhaust particles: assessment of inflammation, oxidative stress and macrophage polarization Particle and Fibre Toxicology 12/1/2018 [PMID: 29716632]
A Micera, A Di Zazzo, G Esposito, R Longo, W Foulsham, R Sacco, R Sgrulletta, S Bonini Age-Related Changes to Human Tear Composition Invest. Ophthalmol. Vis. Sci., 2018-04-01;59(5):2024-2031. 2018-04-01 [PMID: 29677365] (Human)		Human
H Touil, A Kobert, N Lebeurrier, A Rieger, P Saikali, C Lambert, L Fawaz, CS Moore, A Prat, J Gommerman, JP Antel, Y Itoyama, I Nakashima, A Bar-Or Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis J Neuroinflammation, 2018-04-19;15(1):114. 2018-04-19 [PMID: 29673365] (Neutralization, Human)	Neutralization	Human
Linlin Wang, Fang Zhang, Jian‑Ying Cui, Liang Chen, Yue‑Ting Chen, Bo‑Wen Liu CAFs enhance paclitaxel resistance by inducing EMT through the IL‑6/JAK2/STAT3 pathway Oncology Reports 3/14/2018 [PMID: 29565447]
M ?liwi?ska-, S Milnerowic, H Milnerowic Diabetes mellitus secondary to pancreatic diseases (type 3c): The effect of smoking on the exocrine-endocrine interactions of the pancreas Diab Vasc Dis Res, 2018-03-21;0(0):1479164118764. 2018-03-21 [PMID: 29558826] (IHC, Human)	IHC	Human
S Galland, J Vuille, P Martin, I Letovanec, A Caignard, G Fregni, I Stamenkovi Tumor-Derived Mesenchymal Stem Cells Use Distinct Mechanisms to Block the Activity of Natural Killer Cell Subsets Cell Rep, 2017-09-19;20(12):2891-2905. 2017-09-19 [PMID: 28930684] (Neutralization, Human)	Neutralization	Human
R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972. 2017-08-09 [PMID: 28793286] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
D Wang, S Tang, Q Zhang Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway Oncol Lett, 2017-04-21;13(6):4875-4881. 2017-04-21 [PMID: 28599489] (Neutralization, Human)	Neutralization	Human
J Raimbourg, MP Joalland, M Cabart, L de Plater, F Bouquet, A Savina, D Decaudin, J Bennouna, FM Vallette, L Lalier Sensitization of EGFR wild-type non-small cell lung cancer cells to EGFR-tyrosine kinase inhibitor erlotinib Mol. Cancer Ther., 2017-05-18;0(0):. 2017-05-18 [PMID: 28522592] (Neutralization, Human)	Neutralization	Human
J Zhou, C Zhang, J Pan, L Chen, ST Qi Interleukin?6 induces an epithelial?mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration Mol Med Rep, 2017-05-02;15(6):4123-4131. 2017-05-02 [PMID: 28487953] (Neutralization, Human)	Neutralization	Human
P Ortiz-Mont, A Londoño-Va, JP Vernot Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line Cell Commun. Signal, 2017-05-04;15(1):17. 2017-05-04 [PMID: 28472950] (Neutralization, Human)	Neutralization	Human
E Brencicova, AL Jagger, HG Evans, M Georgouli, A Laios, S Attard Mon, G Mehra, J Spencer, AA Ahmed, S Raju-Kanki, LS Taams, SS Diebold Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma PLoS ONE, 2017-04-14;12(4):e0175712. 2017-04-14 [PMID: 28410380] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
H Munir, LS Ward, L Sheriff, S Kemble, S Nayar, F Barone, GB Nash, HM McGettrick Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner Stem Cells, 2017-04-24;0(0):. 2017-04-24 [PMID: 28376564] (Neutralization, Human)	Neutralization	Human
S Chehboun, J Labrecque-, S Pasquin, Y Meliani, B Meddah, W Ferlin, M Sharma, A Tormo, JF Masson, JF Gauchat Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling J. Biol. Chem, 2017-03-09;0(0):. 2017-03-09 [PMID: 28280243] (Neutralization, Mouse)	Neutralization	Mouse
CM Henry, SJ Martin Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory FADDosome Complex upon TRAIL Stimulation Mol. Cell, 2017-02-16;65(4):715-729.e5. 2017-02-16 [PMID: 28212752] (ICC, Human)	ICC	Human
M Chimen, CM Yates, HM McGettrick, LS Ward, MJ Harrison, B Apta, LH Dib, BA Imhof, P Harrison, GB Nash, GE Rainger Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface J. Immunol, 2017-02-13;0(0):. 2017-02-13 [PMID: 28193827] (Neutralization, Human)	Neutralization	Human
HC Hsia, JE Hutti, AS Baldwin Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding kinase 1 (TBK1) to Restrain STAT3 Activity J. Biol. Chem, 2017-02-10;0(0):. 2017-02-10 [PMID: 28188292] (Neutralization, Human)	Neutralization	Human
S Nandana, M Tripathi, P Duan, CY Chu, R Mishra, C Liu, R Jin, H Yamashita, M Zayzafoon, NA Bhowmick, HE Zhau, RJ Matusik, LW Chung Bone metastasis of prostate cancer can be therapeutically targeted at the TBX2-WNT signaling axis Cancer Res, 2017-01-20;0(0):. 2017-01-20 [PMID: 28108510] (Neutralization, Human)	Neutralization	Human
IL-6 trans-signaling is another pathway to upregulate Osteopontin Cytokine, 2016-11-15;90(0):88-95. 2016-11-15 [PMID: 27863335] (Neutralization, Human)	Neutralization	Human
Rusan Catar, Janusz Witowski, Nan Zhu, Christian Lücht, Alicia Derrac Soria, Javier Uceda Fernandez et al. IL-6 Trans–Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane Journal of the American Society of Nephrology 4/1/2017 [PMID: 27837150]
Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium PLoS ONE, 2016-05-12;11(5):e0155161. 2016-05-12 [PMID: 27171357] (Neutralization, Human)	Neutralization	Human
Sheila Ranganath, Ashok Bhandari, Nicole Avitahl-Curtis, Jaimee McMahon, Derek Wachtel, Jenny Zhang et al. Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo PLOS ONE 11/10/2015 [PMID: 26555695]
Manfè Valentina, Fleckner Jan, Nørby Lisby Peder, Zhang Bo, Dai Hongjie, Keller Pernille Cytokine detection and simultaneous assessment of rheumatoid factor interference in human serum and synovial fluid using high-sensitivity protein arrays on plasmonic gold chips BMC Biotechnology 12/1/2015 [PMID: 26268325]
Mar A, Chu C, Lee H, Chien C, Cheng J, Yang S, Jiang J, Lee T Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. J Biol Chem, 2015-07-24;290(36):22212-24. 2015-07-24 [PMID: 26209639] (Neutralization, Mouse)	Neutralization	Mouse
Pathak J, Bakker A, Verschueren P, Lems W, Luyten F, Klein-Nulend J, Bravenboer N CXCL8 and CCL20 Enhance Osteoclastogenesis via Modulation of Cytokine Production by Human Primary Osteoblasts. PLoS ONE, 2015-06-23;10(6):e0131041. 2015-06-23 [PMID: 26103626] (Neutralization, Human)	Neutralization	Human
Maria Hårdstedt, Susanne Lindblom, Alex Karlsson-Parra, Bo Nilsson, Olle Korsgren Characterization of Innate Immunity in an Extended Whole Blood Model of Human Islet Allotransplantation Cell Transplantation 3/1/2016 [PMID: 26084381]
Takeuchi S, Baghdadi M, Tsuchikawa T, Wada H, Nakamura T, Abe H, Nakanishi S, Usui Y, Higuchi K, Takahashi M, Inoko K, Sato S, Takano H, Shichinohe T, Seino K, Hirano S Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer. Cancer Res, 2015-05-07;75(13):2629-40. 2015-05-07 [PMID: 25952647] (Neutralization, Human)	Neutralization	Human
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE, 2015-03-18;10(3):e0119415. 3/18/2015 [PMID: 25785838]
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci, 2015-02-11;35(6):2452-64. 2015-02-11 [PMID: 25673840] (Neutralization, Rat)	Neutralization	Rat
Voltolini C, Battersby S, Novembri R, Torricelli M, Severi F, Petraglia F, Norman J Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition. Endocrinology, 2014-11-26;156(2):670-9. 2014-11-26 [PMID: 25426872] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Kuravi S, McGettrick H, Satchell S, Saleem M, Harper L, Williams J, Rainger G, Savage C Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk. J Immunol, 2014-05-28;193(1):234-43. 2014-05-28 [PMID: 24872191] (Neutralization, Human)	Neutralization	Human
Liu W, Lin Y, Xiao H, Xing S, Chen H, Chi P, Zhang G Epstein-Barr virus infection induces indoleamine 2,3-dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-kappaB pathways: impairment in T cell functions. J Virol, 2014-04-02;88(12):6660-71. 2014-04-02 [PMID: 24696473] (Neutralization, Human)	Neutralization	Human
Oscar Alvarez-Garcia, Nicole H. Rogers, Roy G. Smith, Martin K. Lotz Palmitate Has Proapoptotic and Proinflammatory Effects on Articular Cartilage and Synergizes With Interleukin-1 Arthritis & Rheumatology 7/1/2014 [PMID: 24591481]
Mok J, Mindrinos M, Davis R, Javanmard M Digital microfluidic assay for protein detection. Proc Natl Acad Sci U S A, 2014-01-21;111(6):2110-5. 2014-01-21 [PMID: 24449893] (Immunoassay Development, N/A)	Immunoassay Development	N/A
Todd J, Simpson P, Estis J, Torres V, Wub A Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays. Cytokine, 2013-10-12;64(3):660-5. 2013-10-12 [PMID: 24128872] (ELISA Development, Human)	ELISA Development	Human
Mace T, Ameen Z, Collins A, Wojcik S, Mair M, Young G, Fuchs J, Eubank T, Frankel W, Bekaii-Saab T, Bloomston M, Lesinski G Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res, 2013-03-20;73(10):3007-18. 2013-03-20 [PMID: 23514705] (Neutralization, Human)	Neutralization	Human
Anika I Tsuchida, Michiel Beekhuizen, Marijn Rutgers, Gerjo J V M van Osch, Joris E J Bekkers, Arjan G J Bot et al. Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model Arthritis Research & Therapy 12/3/2012 [PMID: 23206933]
Hubo M et al. Plasmacytoid dendritic cells are inefficient in activation of human regulatory T cells. PLoS One 1/1/2012 [PMID: 22952871]
Nicolaidou V, Wong MM, Redpath AN Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation. PLoS ONE, 2012-07-03;7(7):e39871. 2012-07-03 [PMID: 22802946] (Neutralization, Human)	Neutralization	Human
Zhao X, Qureshi F, Eastman PS, Manning WC, Alexander C, Robinson WH, Hesterberg LK Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis. J. Immunol. Methods, 2012-02-17;378(1):72-80. 2012-02-17 [PMID: 22366959] (ELISA Development, Human)	ELISA Development	Human
Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. J Korean Med Sci, 2011-09-01;26(9):1132-9. 2011-09-01 [PMID: 21935266] (ELISA Development, Human)	ELISA Development	Human
Zepp JA, Nold-Petry CA, Dinarello CA, Nold MF Protection from RNA and DNA viruses by IL-32. J. Immunol., 2011-02-23;186(7):4110-8. 2011-02-23 [PMID: 21346229] (Electrochemiluminescent Assay, Human)	Electrochemiluminescent Assay	Human
Nora Theilacker, Eric E. Roller, Kristopher D. Barbee, Matthias Franzreb, Xiaohua Huang Multiplexed protein analysis using encoded antibody-conjugated microbeads Journal of The Royal Society Interface 8/7/2011 [PMID: 21247950]
Zhan Yao, Silvia Fenoglio, Ding Cheng Gao, Matthew Camiolo, Brendon Stiles, Trine Lindsted et al. TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer Proceedings of the National Academy of Sciences 8/31/2010 [PMID: 20713723]
Lasse Saaby, Anna Katharina Jäger, Lise Moesby, Erik Wind Hansen, Søren Brøgger Christensen Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.) Phytotherapy Research 2/1/2011 [PMID: 20632303]
Tso GH, Law HK, Tu W Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells, 2010-05-01;28(5):939-54. 2010-05-01 [PMID: 20222014] (Neutralization, Human)	Neutralization	Human
Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J. Immunol., 2009-10-07;183(9):5799-806. 2009-10-07 [PMID: 19812208] (ELISA Development, Human)	ELISA Development	Human
Caroline Karlsson, Siv Ahrné, Göran Molin, Anna Berggren, Ingrid Palmquist, Gunilla Nordin Fredrikson et al. Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: A randomized controlled trial Atherosclerosis 1/1/2010 [PMID: 19608185]
Kurago ZB, Lam-ubol A, Stetsenko A Lipopolysaccharide-squamous cell carcinoma-monocyte interactions induce cancer-supporting factors leading to rapid STAT3 activation. Head Neck Pathol, 2008-03-01;2(1):1-12. 2008-03-01 [PMID: 19603082] (Neutralization, Human)	Neutralization	Human
Hu H, Kwun J, Aizenstein BD, Knechtle SJ Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation, 2009-06-27;87(12):1814-20. 2009-06-27 [PMID: 19543058] (Antibody Array Development, Human)	Antibody Array Development	Human
Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol., 2009-05-01;39(5):1221-30. 2009-05-01 [PMID: 19350551] (Neutralization, Human)	Neutralization	Human
Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J. Immunol., 2008-08-15;181(4):2772-80. 2008-08-15 [PMID: 18684968] (Neutralization, Human)	Neutralization	Human
Osei-Kumah A, Smith R, Clifton VL Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Cytokine, 2008-07-17;43(2):187-93. 2008-07-17 [PMID: 18639465] (ELISA Development, Human)	ELISA Development	Human
Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA Endogenous IL-32 controls cytokine and HIV-1 production. J. Immunol., 2008-07-01;181(1):557-65. 2008-07-01 [PMID: 18566422] (Electrochemiluminescent Assay, Human)	Electrochemiluminescent Assay	Human
Kambas K, Markiewski MM, Pneumatikos IA, Rafail SS, Theodorou V, Konstantonis D, Kourtzelis I, Doumas MN, Magotti P, Deangelis RA, Lambris JD, Ritis KD C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome. J. Immunol., 2008-06-01;180(11):7368-75. 2008-06-01 [PMID: 18490736] (Neutralization, Human)	Neutralization	Human
Mitchell CM, Balkus J, Agnew KJ, Cohn S, Luque A, Lawler R, Coombs RW, Hitti JE Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines. AIDS Res. Hum. Retroviruses, 2008-05-01;24(5):667-71. 2008-05-01 [PMID: 18462081] (ELISA Development, Human)	ELISA Development	Human
Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling. Stem Cells, 2007-10-25;26(1):279-89. 2007-10-25 [PMID: 17962701] (ELISA Development, Human)	ELISA Development	Human
Harrison ML, Obermueller E, Maisey NR, Hoare S, Edmonds K, Li NF, Chao D, Hall K, Lee C, Timotheadou E, Charles K, Ahern R, King DM, Eisen T, Corringham R, DeWitte M, Balkwill F, Gore M Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose. J. Clin. Oncol., 2007-10-10;25(29):4542-9. 2007-10-10 [PMID: 17925549] (IHC-Fr, Human)	IHC-Fr	Human
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA Development, Human)	ELISA Development	Human
Arnold R, Neumann M, Konig W Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology, 2007-05-01;121(1):71-81. 2007-05-01 [PMID: 17425601] (Neutralization, Human)	Neutralization	Human
Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M, Buckley CD Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum., 2006-07-01;54(7):2096-108. 2006-07-01 [PMID: 16802344] (Neutralization, Human)	Neutralization	Human
Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G Th2 cytokine response in Major Depressive Disorder patients before treatment. J. Neuroimmunol., 2006-02-02;172(1):156-65. 2006-02-02 [PMID: 16457895] (ELISA Development, Human)	ELISA Development	Human
Holst RM, Mattsby-Baltzer I, Wennerholm UB, Hagberg H, Jacobsson B Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand, 2005-06-01;84(6):551-7. 2005-06-01 [PMID: 15901266] (ELISA Development, Human)	ELISA Development	Human
Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC trans fatty acids and systemic inflammation in heart failure. Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5. 2004-12-01 [PMID: 15585763] (ELISA Development, Human)	ELISA Development	Human
Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254] (Affinity Chromatography, Human)	Affinity Chromatography	Human
Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (Array Development, Human)	Array Development	Human
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest., 2003-08-01;112(4):598-607. 2003-08-01 [PMID: 12925700] (ELISA Development, Human)	ELISA Development	Human
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (ELISA Development, Human)	ELISA Development	Human
Hess S, 2019, Rheinheimer C, Tidow F, Bartling G, Kaps C, Lauber J, Buer J, Klos A The reprogrammed host: Chlamydia trachomatis-induced up-regulation of glycoprotein 130 cytokines, transcription factors, and antiapoptotic genes. 7046, 2001-10-01;44(10):2392-401. 2001-10-01 [PMID: 11665982] (ELISA Development, Human)	ELISA Development	Human
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Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IHC-Fr	Human	01/21/2022	View Summary Application Immunohistochemistry-Frozen Sample Tested Skin tissue Species Human Lot 6708 Comments Comments IL‑6 was detected in immersion fixed frozen sections at 8 ug/ml overnight at 4C.
Enlarge	4 reviewed by: Ruhul Choudhury	IHC-P	Human	03/16/2017	View Summary Application Immunohistochemistry-Paraffin Sample Tested First trimester human decidua Species Human Comments Comments Sodium Citrate antigen retrieval

Array MAB206

• IL-6 Antibodies
• IL-6 Antibody Pair
• IL-6 ELISA Kits
• IL-6 Lysate
• IL-6 Proteins
• IL-6 Proteins and Enzymes
• IL-6 ELISAs