IL-33 Antibody - BSA Free

Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1alpha/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kappaB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: ICC/IF.

Showing Publication 1 - 1 of 1.

Publication using NBP1-76394	Applications	Species
Huang Si-Jian, Yan Jian-Qin, Luo Hui et al. IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-kB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation. J Neuroinflammation 2018-01-01 [PMID: 29329586] (ICC/IF, Rat)	ICC/IF	Rat

Array NBP1-76394

• IL-33 Antibodies
• IL-33 Antibody Pair
• IL-33 ELISA Kits
• IL-33 Lysate
• IL-33 Proteins
• IL-33 ELISAs
• IL-33 Proteins and Enzymes