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IL-22BP/IL22 RA2 Antibody (875504) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
875504
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB10871U-100UG
Alexa Fluor 405
FAB10871V-100UG
Alexa Fluor 488
FAB10871G-100UG
Alexa Fluor 532
FAB10871X
Alexa Fluor 594
FAB10871T-100UG
Alexa Fluor 647
FAB10871R-100UG
Alexa Fluor 700
FAB10871N-100UG
Allophycocyanin
IC10871A-025
Biotin
FAB10871B
CoraFluor 1
FAB10871CL1
DyLight 350
FAB10871D
DyLight 405
FAB10871E
DyLight 488
FAB10871K
DyLight 550
FAB10871L
DyLight 594
FAB10871M
DyLight 650
FAB10871W
DyLight 680
FAB10871Y
DyLight 755
FAB10871Z
FITC
FAB10871F
HRP
FAB10871H
Janelia Fluor 525
FAB10871JF525
Janelia Fluor 549
FAB10871I
Janelia Fluor 646
FAB10871J
Janelia Fluor 669
FAB10871JF669
PE
FAB10871P
PerCP
FAB10871C
Unconjugated
MAB10871
mFluor Violet 450 SE
FAB10871MFV450
mFluor Violet 500 SE
FAB10871MFV500
mFluor Violet 610 SE
FAB10871MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB10871
Carrier Free
MAB10871
Carrier Free
MAB10871-SP
Carrier Free
IC10871A-025
Carrier Free
FAB10871V-100UG
Carrier Free
FAB10871U-100UG
Carrier Free
FAB10871T-100UG
Carrier Free
FAB10871R-100UG
Carrier Free
FAB10871N-100UG
Carrier Free
FAB10871G-100UG
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IL-22BP/IL22 RA2 Antibody (875504) [Alexa Fluor® 750] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL-22BP
Thr22-Pro263
Accession # Q969J5
Specificity
Detects human IL-22BP in direct ELISAs. In direct ELISAs, no cross-reactivity with mouse IL-22BP is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
IL22RA2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-22BP/IL22 RA2 Antibody (875504) [Alexa Fluor® 750]

  • class II cytokine receptor
  • CRF2-10
  • CRF2-S1IL22BP
  • CRF2-X
  • Cytokine receptor class-II member 10
  • Cytokine receptor family 2 member 10
  • Cytokine receptor family type 2, soluble 1
  • IL-22 RA2
  • IL-22 receptor subunit alpha-2
  • IL22BP
  • IL-22BP
  • IL-22BPCRF2X
  • IL22RA2
  • IL-22RA2
  • IL-22R-alpha-2
  • interleukin 22 receptor, alpha 2
  • interleukin 22-binding protein
  • interleukin-22 receptor subunit alpha-2
  • Interleukin-22-binding protein
  • MGC150509
  • MGC150510
  • zcytoR16

Background

Interleukin 22 Binding Protein (IL-22BP), also known as Cytokine Receptor Family (CRF) 2‑10, CRF2-X, and IL-22 RA2, is a secreted glycoprotein belonging to the type II cytokine receptor family. It encodes a precursor protein of 231 amino acid (aa) residues with a 21 aa putative signal peptide and five potential N-linked glycosylation sites. IL-22BP lacks a transmembrane and cytoplasmic domain and is most closely related to the extracellular domains of IL‑22 R (CRF2-9) and IL-20 R (CRF2-8), sharing 33% and 34% aa sequence identity, respectively. It also shares sequence homology with the extracellular domains of IL-10 R (29%), IL-10 R beta (30%), the IFN receptors (23‑25%) and tissue factor (26%). IL-22BP antagonizes IL-22 activity by specifically binding IL-22 with high affinity and blocking its interaction with the cell surface IL-22 receptor heteromeric complex composed IL-22 R and IL‑20 R. IL-22BP is expressed in multiple tissues. The highest levels of expression are found in breast, lungs and colon. The major cell types producing IL-22BP are monocytes, activated B cells and epithelial cells (1), and is constitutively expressed by a subset of conventional dendritic cells (2). IL-22BP is regulated by the inflammasome and it has been suggested to modulate tumorigenesis in the intestine (3).

  1. Xu, W. et al. (2001) Proc. Natl. Acad. Sci. USA 98:9511.
  2. Martin, J. et al. (2014)  Mucosal Immunol. 7:101.
  3. Huber, S. et al. (2012)  Nature 491:259.

    Limitations

    This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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    Secondary Antibodies

    		 

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    Bioinformatics

    Gene Symbol IL22RA2
    Uniprot