Name: IL-2 Antibody (5334) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB202
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	B/N, CyTOF-ready, Flow, ICC/IF
Clone	5334
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 IC202U-100UG

Alexa Fluor 405 IC202V-100UG

Alexa Fluor 488 IC202G-100UG

Alexa Fluor 532 FAB202X

Alexa Fluor 594 IC202T-100UG

Alexa Fluor 647 IC202R-100UG

Alexa Fluor 700 IC202N-100UG

Alexa Fluor 750 IC202S-100UG

Allophycocyanin FAB202A

Biotin FAB202B

CoraFluor 1 FAB202CL1

DyLight 350 FAB202D

DyLight 405 FAB202E

DyLight 488 FAB202K

DyLight 550 FAB202L

DyLight 594 FAB202M

DyLight 650 FAB202W

DyLight 680 FAB202Y

DyLight 755 FAB202Z

FITC FAB202F

HRP FAB202H

Janelia Fluor 525 FAB202JF525

Janelia Fluor 549 FAB202I

Janelia Fluor 585 FAB202JF585

Janelia Fluor 635 FAB202JF635

Janelia Fluor 646 FAB202J

Janelia Fluor 669 FAB202JF669

PerCP FAB202C

Phycoerythrin IC202P

mFluor Violet 450 SE FAB202MFV450

mFluor Violet 500 SE FAB202MFV500

mFluor Violet 610 SE FAB202MFV610

Catalog# & Formulation	Size	Price
Carrier Free IC202P

Carrier Free MAB202-SP

Carrier Free MAB202-500

Carrier Free IC202N-100UG

Carrier Free IC202G-100UG

Carrier Free IC202V-100UG

Carrier Free IC202U-100UG

Carrier Free IC202T-100UG

Carrier Free IC202S-100UG

Carrier Free IC202R-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	IC202U-100UG
Alexa Fluor 405	IC202V-100UG
Alexa Fluor 488	IC202G-100UG
Alexa Fluor 532	FAB202X
Alexa Fluor 594	IC202T-100UG
Alexa Fluor 647	IC202R-100UG
Alexa Fluor 700	IC202N-100UG
Alexa Fluor 750	IC202S-100UG
Allophycocyanin	FAB202A
Biotin	FAB202B
CoraFluor 1	FAB202CL1
DyLight 350	FAB202D
DyLight 405	FAB202E
DyLight 488	FAB202K
DyLight 550	FAB202L
DyLight 594	FAB202M
DyLight 650	FAB202W
DyLight 680	FAB202Y
DyLight 755	FAB202Z
FITC	FAB202F
HRP	FAB202H
Janelia Fluor 525	FAB202JF525
Janelia Fluor 549	FAB202I
Janelia Fluor 585	FAB202JF585
Janelia Fluor 635	FAB202JF635
Janelia Fluor 646	FAB202J
Janelia Fluor 669	FAB202JF669
PerCP	FAB202C
Phycoerythrin	IC202P
mFluor Violet 450 SE	FAB202MFV450
mFluor Violet 500 SE	FAB202MFV500
mFluor Violet 610 SE	FAB202MFV610

IL-2 Antibody (5334) [Unconjugated]

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IL-2 Antibody (5334) [Unconjugated] Summary

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Alternate Names for IL-2 Antibody (5334) [Unconjugated]

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Publications for IL-2 Antibody (MAB202)(26)

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Immunogen	E. coli-derived recombinant human IL‑2 Ala21-Thr153 Accession # NP_000577
Specificity	Detects human IL-2 in direct ELISAs. Does not cross-react with recombinant IL-2 from mouse, rat, pig, or cotton rat.
Source	N/A
Isotype	IgG1
Clonality	Monoclonal
Host	Mouse
Gene	IL2
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB202	Applications	Species
Moore, GL;Zeng, VG;Diaz, JE;Bonzon, C;Avery, KN;Rashid, R;Qi, J;Nam, DH;Jacinto, J;Dragovich, MA;Kim, YK;Balcazar, KP;Bakhit, CG;Eivazi, A;Nguyen, H;Muchhal, US;Szymkowski, DE;Desjarlais, JR;Hedvat, M; A B7-H3-targeted CD28 bispecific antibody enhances the activity of anti-PD1 and CD3 T-cell engager immunotherapies Molecular cancer therapeutics 2024-09-20 [PMID: 39301613] (Neutralization, Human)	Neutralization	Human
Zheng N, Fang J, Xue G et al. Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance Cancer cell 8/15/2022 [PMID: 36027915]
M Ukita, J Hamanishi, H Yoshitomi, K Yamanoi, S Takamatsu, A Ueda, H Suzuki, Y Hosoe, Y Furutake, M Taki, K Abiko, K Yamaguchi, H Nakai, T Baba, N Matsumura, A Yoshizawa, H Ueno, M Mandai CXCL13-producing CD4+ T cells accumulate in early phase of tertiary lymphoid structures in ovarian cancer JCI Insight, 2022-06-22;0(0):. 2022-06-22 [PMID: 35552285] (Neutralization, Human)	Neutralization	Human
Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie et al. Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip Advanced Science 2022-05-01 [PMID: 35289122]
Rosemina Merchant, Carole Galligan, Manjunatha Ankathatti Munegowda, L Bruce Pearce, Peter Lloyd, Paul Smith et al. Fine-tuned long-acting interleukin-2 superkine potentiates durable immune responses in mice and non-human primate Journal for ImmunoTherapy of Cancer 2022-01-19 [PMID: 35058325]
Y Rodríguez-, LG Batista-Ro, A Llopiz-Arz, P Puente-Pér, R Martínez-C, J Castro-Vel, A Santos-Sav Immunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15 BMC immunology, 2021-12-18;22(1):79. 2021-12-18 [PMID: 34922462] (Neutralization, Mouse)	Neutralization	Mouse
Hiroshi Kato, Andras Perl Double-Edged Sword: Interleukin-2 Promotes T Regulatory Cell Differentiation but Also Expands Interleukin-13- and Interferon-gamma -Producing CD8+ T Cells via STAT6-GATA-3 Axis in Systemic Lupus Erythematosus Frontiers in Immunology 2021-03-02 [PMID: 33763079]
D Sahin, N Arenas-Ram, M Rath, U Karakus, M Hümbelin, M van Gogh, L Borsig, O Boyman An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer Nature Communications, 2020-12-22;11(1):6440. 2020-12-22 [PMID: 33353953] (ELISA Detection, Human, Mouse)	ELISA Detection	Human, Mouse
Valentin Haug, Branislav Kollar, Sotirios Tasigiorgos, Yori Endo, Martin Kauke, Ali-Farid Safi et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours Transplantation 2020-09-01 [PMID: 32168040]
A Güler, ML Venegas, E Adankwah, E Mayatepek, N Nausch, M Jacobsen Suppressor of cytokine signaling 3 is crucial for interleukin-7 receptor re-expression after T-cell activation and interleukin-7 dependent proliferation Eur. J. Immunol., 2019-11-14;0(0):. 2019-11-14 [PMID: 31621896] (Neutralization, Human)	Neutralization	Human
JH Kim, SJ Jang, JW Yun, MH Jung, SH Woo Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro PLoS ONE, 2018-11-08;13(11):e0207090. 2018-11-08 [PMID: 30408092] (Neutralization, Human)	Neutralization	Human
T Carmenate, Y Ortíz, M Enamorado, K García-Mar, J Avellanet, E Moreno, L Graça, K León Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Regulatory T Cells J. Immunol., 2018-04-04;0(0):. 2018-04-04 [PMID: 29618524] (Bioassay, Human)	Bioassay	Human
S Revu, J Wu, M Henkel, N Rittenhous, A Menk, GM Delgoffe, AC Poholek, MJ McGeachy IL-23 and IL-1? Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation Cell Rep, 2018-03-06;22(10):2642-2653. 2018-03-06 [PMID: 29514093] (Neutralization, Human)	Neutralization	Human
Lauryn E. Klevorn, Melissa M. Berrien-Elliott, Jinyun Yuan, Lindsey M. Kuehm, Gregory D. Felock, Sean A. Crowe et al. Rescue of Tolerant CD8+ T Cells during Cancer Immunotherapy with IL2:Antibody Complexes Cancer Immunology Research 2016-12-01 [PMID: 27803062]
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling Sci Rep, 2016-09-02;6(0):32320. 2016-09-02 [PMID: 27586092] (Flow Cytometry, Neutralization, Human)	Flow Cytometry, Neutralization	Human
Activin A programs the differentiation of human TFH cells Nat Immunol, 2016-07-04;17(8):976-84. 2016-07-04 [PMID: 27376469] (Bioassay, Human)	Bioassay	Human
Jürgen Knobloch, Sarah-Jane Chikosi, Sarah Yanik, Jan Rupp, David Jungck, Andrea Koch A systemic defect in Toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPD American Journal of Physiology-Lung Cellular and Molecular Physiology 2016-01-01 [PMID: 26498252]
Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, Azimi N, Tagaya Y Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum. J Biol Chem, 2015-07-16;290(37):22338-51. 2015-07-16 [PMID: 26183780] (Neutralization, Human)	Neutralization	Human
Kim , Dae Won, Zloza , Andrew, Broucek , Joseph, Schenkel , Jason M, Ruby , Carl, Samaha , Georges, Kaufman , Howard L Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med, 2014-05-06;12(0):113. 2014-05-06 [PMID: 24885155] (Neutralization, Human)	Neutralization	Human
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation. Blood, 2012-05-10;119(26):6268-77. 2012-05-10 [PMID: 22577174] (Neutralization, Human)	Neutralization	Human
Rathi L. Srinivas, Stephen C. Chapin, Patrick S. Doyle Aptamer-Functionalized Microgel Particles for Protein Detection Analytical Chemistry 2011-12-01 [PMID: 22017663]
Hutnick NA, Carnathan D, Demers K, Makedonas G, Ertl HC, Betts MR Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive. Vaccine, 2010-02-23;28(8):1932-41. 2010-02-23 [PMID: 20188249] (Flow Cytometry, Human)	Flow Cytometry	Human
Withers DR, Fiorini C, Fischer RT, Ettinger R, Lipsky PE, Grammer AC T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue. Blood, 2007-02-13;109(11):4856-64. 2007-02-13 [PMID: 17299094] (Neutralization, Human)	Neutralization	Human
Karenko L, Hahtola S, Paivinen S, Karhu R, Syrja S, Kahkonen M, Nedoszytko B, KytÃƒÂ¶lÃƒÂ¤ S, Zhou Y, Blazevic V, Pesonen M, Nevala H, Nupponen N, Sihto H, Krebs I, Poustka A, Roszkiewicz J, Saksela K, Peterson P, Visakorpi T, Ranki A Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer Res., 2005-09-15;65(18):8101-10. 2005-09-15 [PMID: 16166283] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology, 2004-06-01;112(2):274-89. 2004-06-01 [PMID: 15147571] (Flow Cytometry, Human)	Flow Cytometry	Human
Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB Reprogramming of IL-10 activity and signaling by IFN-gamma. J. Immunol., 2003-11-15;171(10):5034-41. 2003-11-15 [PMID: 14607900] (Neutralization, Human)	Neutralization	Human
Show All 26 Publications. Collapse Publications.

Gene Symbol	IL2
Uniprot	NP_000577()