IL-1ra/IL-1F3/IL1RN Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha . It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells, but reportedly will not block binding to the type II receptor on murine pre-B cell lines. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Currently, pre-clinical and clinical studies are underway to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 5 applications: ICC, IHC, IHC-Fr, Neutralization, Western Blot.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using AF-280-NA	Applications	Species
Vukovic, M;Chamlati, JM;Hennenlotter, J;Todenhöfer, T;Lütfrenk, T;Jersinovic, S;Tsaur, I;Stenzl, A;Rausch, S; Interleukin-1?/Interleukin (IL)-1-Receptor-Antagonist (IL1-RA) Axis in Invasive Bladder Cancer-An Exploratory Analysis of Clinical and Tumor Biological Significance International journal of molecular sciences 2024-02-19 [PMID: 38397123] (IHC, Human)	IHC	Human
Y Chen, Z Yang, B Deng, D Wu, Y Quan, Z Min Interleukin 1&beta/1RA axis in colorectal cancer regulates tumor invasion, proliferation and apoptosis via autophagy Oncol. Rep., 2020-01-22;43(3):908-918. 2020-01-22 [PMID: 32020215] (IHC, Human)	IHC	Human
Hull RL, Gibson RL, McNamara S et al. Islet Interleukin-1beta Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to beta-Cell Failure. Diabetes Care 4/1/2018 [PMID: 29437698]
DJ Kota, KS Prabhakara, N Toledano-F, D Bhattarai, Q Chen, B DiCarlo, P Smith, F Triolo, PL Wenzel, CS Cox, SD Olson Prostaglandin E2 Indicates Therapeutic Efficacy Of Mesenchymal Stem Cells In Experimental Traumatic Brain Injury Stem Cells, 2017-03-16;0(0):. 2017-03-16 [PMID: 28233425] (Western Blot, Human)	Western Blot	Human
JH Lee, EH Kam, JM Kim, SY Kim, EJ Kim, SY Cheon, BN Koo Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model Biomol Ther (Seoul), 2017-03-01;25(2):149-157. 2017-03-01 [PMID: 27530114] (IHC, Rat)	IHC	Rat
Rider P, Carmi Y, Yossef R, Guttman O, Eini H, Azam T, Dinarello C, Lewis E IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation. J Immunol, 2015-07-08;195(4):1705-12. 2015-07-08 [PMID: 26157171] (Western Blot, Human)	Western Blot	Human
Megjugorac NJ, Gallagher GE, Gallagher G IL-4 enhances IFN-lambda1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra. Blood, 2010-03-16;115(21):4185-90. 2010-03-16 [PMID: 20233967] (Neutralization, Human)	Neutralization	Human
van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. Dig. Dis. Sci., 2007-03-30;52(10):2775-83. 2007-03-30 [PMID: 17394066] (ICC, Human)	ICC	Human
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells. Br. J. Pharmacol., 2007-03-12;151(1):115-27. 2007-03-12 [PMID: 17351655] (Western Blot, Human)	Western Blot	Human
Grundtman C, Salomonsson S, Dorph C, Bruton J, Andersson U, Lundberg IE Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies. Arthritis Rheum., 2007-02-01;56(2):674-87. 2007-02-01 [PMID: 17265504] (ICC, IHC-Fr, Human)	ICC, IHC-Fr	Human
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R IL-22 increases the innate immunity of tissues. Immunity, 2004-08-01;21(2):241-54. 2004-08-01 [PMID: 15308104] (Neutralization, Human)	Neutralization	Human
Hakonarson H, Whelan R, Leiter J, Kim C, Chen M, Campbell D, Grunstein MM T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta. J. Allergy Clin. Immunol., 2002-10-01;110(4):624-33. 2002-10-01 [PMID: 12373272] (Neutralization, Human)	Neutralization	Human
Show All 12 Publications. Collapse Publications.

Array AF-280-NA

• IL-1ra/IL-1F3/IL1RN Antibodies
• IL-1ra/IL-1F3/IL1RN ELISA Kits
• IL-1ra/IL-1F3/IL1RN Lysates
• IL-1ra/IL-1F3/IL1RN Proteins
• IL-1ra/IL-1F3/IL1RN Proteins and Enzymes
• IL-1ra/IL-1F3/IL1RN ELISAs