IL-12/IL-35 p35 Antibody (27537) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 12 (IL-12) and interleukin 35 (IL-35) are heterodimeric cytokines composed of alpha and beta chains. IL-12 is composed of p35 and p40 subunits, while IL-35 is comprised of p35 paired with EBI-3 (1). In mice, IL-35 is produced by FoxP3⁺ regulatory T cells and may function as an inhibitory cytokine to suppress T cell proliferation (2). Human FoxP3⁺ Tregs do not constitutively express IL-35 (3), but expression may be induced by activated dendritic cells (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 8 of 8.

Publications using IC2191P	Applications	Species
AT Alshareeda, E Rakha, A Alghwainem, B Alrfaei, B Alsowayan, A Albugami, AM Alsubayyil, M Abomraee, NK Mohd Zin The effect of human placental chorionic villi derived mesenchymal stem cell on triple-negative breast cancer hallmarks PLoS ONE, 2018-11-20;13(11):e0207593. 2018-11-20 [PMID: 30458011] (Flow Cytometry, Human)	Flow Cytometry	Human
Hong‑Xia Wang, Xia Kang, Shuai Chu, Haixia Li, Xin Li, Xiaofeng Yin et al. Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells�in patients with rheumatoid arthritis Experimental and Therapeutic Medicine 2018-08-24 [PMID: 30233732]
M Komorowski, J Tisonczyk, A Kolakowska, R Drozdz, D Kozbor Modulation of the Tumor Microenvironment by CXCR4 Antagonist-Armed Viral Oncotherapy Enhances the Antitumor Efficacy of Dendritic Cell Vaccines against Neuroblastoma in Syngeneic Mice Viruses, 2018-08-26;10(9):. 2018-08-26 [PMID: 30149659] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Marcin P Komorowski Reprogramming antitumor immunity against chemoresistant ovarian cancer by a CXCR4 antagonist-armed viral oncotherapy Mol Ther Oncolytics, 2016-12-14;3(0):16034. 2016-12-14 [PMID: 28035333] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Richter C, Thieme S, Bandola J, Laugsch M, Anastassiadis K, Brenner S Generation of inducible immortalized dendritic cells with proper immune function in vitro and in vivo. PLoS ONE, 2013-04-23;8(4):e62621. 2013-04-23 [PMID: 23626840] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Pina A, de Araujo E, Felonato M, Loures F, Feriotti C, Bernardino S, Barbuto J, Calich V Myeloid dendritic cells (DCs) of mice susceptible to paracoccidioidomycosis suppress T cell responses whereas myeloid and plasmacytoid DCs from resistant mice induce effector and regulatory T cells. Infect Immun, 2013-01-22;81(4):1064-77. 2013-01-22 [PMID: 23340311] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells. Biochem Biophys Res Commun, 2012-11-12;430(1):364-9. 2012-11-12 [PMID: 23154182] (Flow Cytometry, Human)	Flow Cytometry	Human
Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J. Immunol., 2011-05-16;186(12):6661-6. 2011-05-16 [PMID: 21576509] (Flow Cytometry, Human)	Flow Cytometry	Human

Array IC2191P

• IL-12/IL-35 p35 Antibodies
• IL-12/IL-35 p35 ELISA Kits