Name: IL-11 Antibody (22626) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB218
Price: 559 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, B/N
Clone	22626
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB218U

Alexa Fluor 405 FAB218V

Alexa Fluor 488 FAB218G

Alexa Fluor 532 FAB218X

Alexa Fluor 594 FAB218T

Alexa Fluor 647 FAB218R

Alexa Fluor 700 FAB218N

Alexa Fluor 750 FAB218S

Allophycocyanin FAB218A

Biotin FAB218B

DyLight 350 FAB218D

DyLight 405 FAB218E

DyLight 488 FAB218K

DyLight 550 FAB218L

DyLight 594 FAB218M

DyLight 650 FAB218W

DyLight 680 FAB218Y

DyLight 755 FAB218Z

FITC FAB218F

HRP FAB218H

Janelia Fluor 525 FAB218JF525

Janelia Fluor 549 FAB218I

Janelia Fluor 646 FAB218J

Janelia Fluor 669 FAB218JF669

PerCP FAB218C

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB218U
Alexa Fluor 405	FAB218V
Alexa Fluor 488	FAB218G
Alexa Fluor 532	FAB218X
Alexa Fluor 594	FAB218T
Alexa Fluor 647	FAB218R
Alexa Fluor 700	FAB218N
Alexa Fluor 750	FAB218S
Allophycocyanin	FAB218A
Biotin	FAB218B
DyLight 350	FAB218D
DyLight 405	FAB218E
DyLight 488	FAB218K
DyLight 550	FAB218L
DyLight 594	FAB218M
DyLight 650	FAB218W
DyLight 680	FAB218Y
DyLight 755	FAB218Z
FITC	FAB218F
HRP	FAB218H
Janelia Fluor 525	FAB218JF525
Janelia Fluor 549	FAB218I
Janelia Fluor 646	FAB218J
Janelia Fluor 669	FAB218JF669
PerCP	FAB218C

Immunogen	E. coli-derived recombinant human IL‑11 Pro22-Leu199 Accession # P20809
Specificity	Detects human IL-11 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse IL-11 is observed and no cross-reactivity with recombinant human (rh) IL-6, rhCNTF, rhLIF, rhOSM, rhCLC, or rhCT-1 is observed.
Source	N/A
Isotype	IgG2a
Clonality	Monoclonal
Host	Mouse
Gene	IL11
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

IL-11 Antibody (22626) [Unconjugated]

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IL-11 Antibody (22626) [Unconjugated] Summary

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Alternate Names for IL-11 Antibody (22626) [Unconjugated]

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Publications for IL-11 Antibody (MAB218)(13)

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Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB218	Applications	Species
Sweeney, M;O'Fee, K;Villanueva-Hayes, C;Rahman, E;Lee, M;Vanezis, K;Andrew, I;Lim, WW;Widjaja, A;Barton, PJR;Cook, SA; Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction International journal of molecular sciences 2023-08-20 [PMID: 37629170] (Western Blot, Mouse)	Western Blot	Mouse
AA Widjaja, S Viswanatha, SG Shekeran, E Adami, WW Lim, S Chothani, J Tan, JWT Goh, HM Chen, SY Lim, CM Boustany-K, J Hawkins, E Petretto, N Hübner, S Schafer, TM Coffman, SA Cook Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease Nature Communications, 2022-12-05;13(1):7497. 2022-12-05 [PMID: 36470928] (Neutralization, Mouse)	Neutralization	Mouse
Anissa A. Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K. Singh, Jessie Tan, Joyce Goh Wei Ting et al. Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts Frontiers in Molecular Biosciences 2021-09-28 [PMID: 34651016]
E Dzia?o, M Czepiel, K Tkacz, M Siedlar, G Kania, P B?yszczuk WNT/beta-Catenin Signaling Promotes TGF-beta-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production International Journal of Molecular Sciences, 2021-09-17;22(18):. 2021-09-17 [PMID: 34576234] (Neutralization, Human)	Neutralization	Human
Z Chen, X Chen, R Xie, M Huang, W Dong, J Han, J Zhang, Q Zhou, H Li, J Huang, T Lin DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression Mol. Ther., 2019-01-09;27(2):326-341. 2019-01-09 [PMID: 30660488] (Inhibition, Human)	Inhibition	Human
M Zhao, Y Liu, R Liu, J Qi, Y Hou, J Chang, L Ren Upregulation of IL-11, an IL-6 Family Cytokine, Promotes Tumor Progression and Correlates with Poor Prognosis in Non-Small Cell Lung Cancer Cell. Physiol. Biochem., 2018-03-10;45(6):2213-2224. 2018-03-10 [PMID: 29550807] (Neutralization, Human)	Neutralization	Human
S Schafer, S Viswanatha, AA Widjaja, WW Lim, A Moreno-Mor, DM DeLaughter, B Ng, G Patone, K Chow, E Khin, J Tan, SP Chothani, L Ye, OJL Rackham, NSJ Ko, NE Sahib, CJ Pua, NTG Zhen, C Xie, M Wang, H Maatz, S Lim, K Saar, S Blachut, E Petretto, S Schmidt, T Putoczki, N Guimarães-, H Wakimoto, S van Heesch, K Sigmundsso, SL Lim, JL Soon, VTT Chao, YL Chua, TE Tan, SM Evans, YJ Loh, MH Jamal, KK Ong, KC Chua, BH Ong, MJ Chakaramak, JG Seidman, CE Seidman, N Hubner, KYK Sin, SA Cook IL-11 is a crucial determinant of cardiovascular fibrosis Nature, 2017-11-13;552(7683):110-115. 11/13/2017 [PMID: 29160304]
Kouhei Tsumoto Production and characterization of genetically modified human IL-11 variants Biochim. Biophys. Acta, 2016-11-22;1861(2):205-217. 2016-11-22 [PMID: 27884519] (Western Blot)	Western Blot
Zhou C, Ji J, Cai Q, Shi M, Chen X, Yu Y, Zhu Z, Zhang J MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11. BMC Cancer, 2015-05-02;15(0):343. 2015-05-02 [PMID: 25929737] (Neutralization, Human)	Neutralization	Human
Kim J, Kim M, Ham A, Brown K, Greene R, D'Agati V, Lee H IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI. J Am Soc Nephrol, 2013-06-27;24(10):1558-70. 2013-06-27 [PMID: 23813214] (Neutralization, Human)	Neutralization	Human
Onnis , Barbara, Fer , Nicole, Rapisarda , Annamari, Perez , Victor S, Melillo , Giovanni Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. J Clin Invest, 2013-03-15;123(4):1615-29. 2013-03-15 [PMID: 23549086] (Neutralization, Human)	Neutralization	Human
Bockhorn , Jessica, Dalton , Rachel, Nwachukwu , Chika, Huang , Simo, Prat , Aleix, Yee , Kathy, Chang , Ya-Fang, Huo , Dezheng, Wen , Yujia, Swanson , Kaitlin, Qiu , Tyler, Lu , Jun, Park , Seo Youn, Dolan , M Eileen, Perou , Charles, Olopade , Olufunmi, Clarke , Michael, Greene , Geoffrey, Liu , Huiping MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun, 2013-01-01;4(0):1393. 2013-01-01 [PMID: 23340433] (Neutralization, Human)	Neutralization	Human
Kai Syin Lee, Anastasia Kalantzis, Cameron B. Jackson, Louise O'Connor, Naoko Murata-Kamiya, Masanori Hatakeyama et al. Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3 gamma via Gastric STAT3 Activation PLoS ONE 2012-02-01 [PMID: 22312430]
Show All 13 Publications. Collapse Publications.

Catalog# & Formulation	Size	Price
Carrier Free MAB218-SP

Gene Symbol	IL11
Uniprot	P20809()