Recombinant Human IFN-gamma Protein

This lyophilized preparation is stable for 12 months from date of receipt at -20 to -70 degrees C, preferably desiccated. Upon reconstitution, the preparation can be stored for 1 month at 2-8 degrees C under sterile conditions, and for 3 months at -20 degrees C to -70 degrees C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Stock solutions should be aliquoted and stored at < -20 degrees C. Further dilutions should be made in appropriate buffered solutions

Interferon-gamma (IFN-gamma), also known as Type II interferon or immune interferon, is a cytokine produced primarily by Tlymphocytes and natural killer cells. The protein shares no significant homology with IFN-beta or the various IFN-alpha family proteins. Mature IFN-gamma exists as noncovalently-linked homodimers. Human IFN-gamma is highly species specific and is biologically active only in human and primate cells. IFN-gamma was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-gamma induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-gamma also augments TH1 cell expansion and may be required for TH1 cell differentiation

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioactivity, In vitro.

Showing Publications 1 - 7 of 7.

Publications using NBP2-34992	Applications	Species
Gong P, Ding Y, Sun R et al. Mesenchymal stem cells alleviate systemic sclerosis by inhibiting the recruitment of pathogenic macrophages Cell death discovery 2022-11-26 [PMID: 36435837]
Schiefer S, Hale B Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by the E3 ubiquitin ligase PJA2 bioRxiv 2023-10-09 (In vitro)	In vitro
Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen, Guixue Wang M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation Theranostics 2020-01-01 [PMID: 32929376]
Zhu M, Chu Y, Shang Q et al. Mesenchymal stromal cells pretreated with pro-inflammatory cytokines promote skin wound healing through VEGFC-mediated angiogenesis Stem Cells Transl Med 2020-06-13 [PMID: 32534464] (Human)		Human
Wu J, Zhang XX, Zou X et al. The effect of Jianpi Yangzheng Xiaozheng Decoction and its components on gastric cancer J Ethnopharmacol 2019-02-05 [PMID: 30731181] (Bioactivity, Human)	Bioactivity	Human
Wang L, Yang X, Li D et al. The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-g. bioRxiv. 2018-10-31 [PMID: 30425515]
Jiasi Wu, 1, Hai Zhang et al. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Eur J Pharmacol 2016-06-05 [PMID: 27018392]

Array NBP2-34992

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes