IFN-gamma Antibody (37895) [Fluorescein]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma, IFNG), also known as type II or Immune Interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa molecular weight variably glycosylated subunits. It shares 86% amino acid (aa) sequence identity with rat IFN-gamma, 38-44% with bovine, canine, cotton rat, equine, feline, human, porcine and rhesus IFN‑ gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rabbit.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 6 of 6.

Publications using IC485F	Applications	Species
Fernando, V;Zheng, X;Sharma, V;Furuta, S; Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism bioRxiv : the preprint server for biology 8/22/2023 [PMID: 37662241]
Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue Acta Neuropathol Commun, 2016-09-06;4(1):100. 2016-09-06 [PMID: 27600707] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am. J. Respir. Cell Mol. Biol., 2006-12-01;36(4):442-51. 2006-12-01 [PMID: 17142310] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Hu J, Peng X, Schell TD, Budgeon LR, Cladel NM, Christensen ND An HLA-A2.1-transgenic rabbit model to study immunity to papillomavirus infection. J. Immunol., 2006-12-01;177(11):8037-45. 2006-12-01 [PMID: 17114477] (Flow Cytometry, Rabbit)	Flow Cytometry	Rabbit
Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. J Ethnopharmacol, 2006-10-19;110(3):532-8. 2006-10-19 [PMID: 17101254] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Utting O, Sedgmen BJ, Watts TH, Shi X, Rottapel R, Iulianella A, Lohnes D, Veillette A Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Mol. Cell. Biol., 2004-07-01;24(13):6067-75. 2004-07-01 [PMID: 15199160] (Flow Cytometry, Human)	Flow Cytometry	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Mahesh Raundhal	Flow	Mouse	12/23/2018	View Summary Application Flow Cytometry Sample Tested T cells Species Mouse Lot LJS0614101

Array IC485F

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes