IFN-gamma Antibody (25723) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma, IFNG), also known as type II or Immune Interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa molecular weight variably glycosylated subunits. Glycosylation of IFN-gamma at sites Asn25 and Asn97 is critical for protease resistance. It shares 90% amino acid (aa) sequence identity with rhesus IFN-gamma, 59-64% with bovine, canine, equine, feline, and porcine IFN‑ gamma, and 37-43% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: Chip Cytometry, Flow Cytometry, ICC, IHC-P, Neutralization.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using IC285P	Applications	Species
Subayyil, AA;Basmaeil, YS;Kulayb, HB;Alrodayyan, M;Alhaber, LAA;Almanaa, TN;Khatlani, T; Preconditioned Chorionic Villus Mesenchymal Stem/Stromal Cells (CVMSCs) Minimize the Invasive Phenotypes of Breast Cancer Cell Line MDA231 In Vitro International journal of molecular sciences 2023-05-31 [PMID: 37298519] (Flow Cytometry, Human)	Flow Cytometry	Human
H Vietzen, S Hartenberg, SW Aberle, E Puchhammer Dissection of the NKG2C NK cell response against Puumala Orthohantavirus PloS Neglected Tropical Diseases, 2021-12-06;15(12):e0010006. 2021-12-06 [PMID: 34871302] (Flow Cytometry, Human)	Flow Cytometry	Human
M Barone, L Mendozzi, F D'Amico, M Saresella, S Rampelli, F Piancone, F La Rosa, I Marventano, M Clerici, A d'Arma, L Pugnetti, V Rossi, M Candela, P Brigidi, S Turroni Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis International Journal of Molecular Sciences, 2021-07-02;22(13):. 2021-07-02 [PMID: 34281224] (ICC, Human)	ICC	Human
Shirin Kalimuddin, Christine Y.L. Tham, Martin Qui, Ruklanthi de Alwis, Jean X.Y. Sim, Joey M.E. Lim et al. Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset Med (N Y) 6/1/2021 [PMID: 33851143]
AT Tan, M Linster, CW Tan, N Le Bert, WN Chia, K Kunasegara, Y Zhuang, CYL Tham, A Chia, GJD Smith, B Young, S Kalimuddin, JGH Low, D Lye, LF Wang, A Bertoletti Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients Cell Reports, 2021-01-21;34(6):108728. 2021-01-21 [PMID: 33516277] (Flow Cytometry, Human)	Flow Cytometry	Human
Kelsey Voss, Christopher R. Luthers, Katherine Pohida, Andrew L. Snow Fatty Acid Synthase Contributes to Restimulation-Induced Cell Death of Human CD4 T Cells Frontiers in Molecular Biosciences 10/15/2019 [PMID: 31681794]
DJ Kaczmarek, P Kokordelis, B Krämer, A Glässner, F Wolter, F Goeser, P Lutz, C Schwarze-Z, C Boesecke, CP Strassburg, JK Rockstroh, U Spengler, J Nattermann Alterations of the NK cell pool in HIV/HCV co-infection PLoS ONE, 2017-04-05;12(4):e0174465. 4/5/2017 [PMID: 28380039]
Linna Xie Serum microRNA181a: Correlates with the intracellular cytokine levels and a potential biomarker for acute graft-versus-host disease Cytokine, 2016-06-08;85(0):37-44. 2016-06-08 [PMID: 27288630] (Flow Cytometry, Human)	Flow Cytometry	Human
Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med, 2015-04-27;212(5):619-31. 2015-04-27 [PMID: 25918342] (Neutralization, Human)	Neutralization	Human
Hagen J, Zimmerman R, Goetz C, Bonnevier J, Houchins J, Reagan K, Kalyuzhny A Comparative Multi-Donor Study of IFNgamma Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells, 2015-02-11;4(1):84-95. 2015-02-11 [PMID: 25679284] (Flow Cytometry, Human)	Flow Cytometry	Human
Hennig C, Ilginus C, Boztug K, Skokowa J, Marodi L, Szaflarska A, Sass M, Pignata C, Kilic S, Caragol I, Baumann U, Klein C, Welte K, Hansen G High-content cytometry and transcriptomic biomarker profiling of human B-cell activation. J Allergy Clin Immunol, 2013-09-05;133(1):172-80.e1-10. 2013-09-05 [PMID: 24012209] (Chip Cytometry, Human)	Chip Cytometry	Human
Chang C, Tan A, Or M, Toh K, Lim P, Chia A, Froesig T, Nadua K, Oh H, Leong H, Hadrup S, Gehring A, Tan Y, Bertoletti A, Grotenbreg G Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases. Eur J Immunol, 2013-02-14;43(4):1109-20. 2013-02-14 [PMID: 23280567] (ICC, Human)	ICC	Human
Glassner A, Eisenhardt M, Kramer B, Korner C, Coenen M, Sauerbruch T, Spengler U, Nattermann J NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. Lab. Invest., 2012-03-26;92(7):967-77. 2012-03-26 [PMID: 22449797] (Flow Cytometry, Human)	Flow Cytometry	Human
Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther, 2011-11-10;19(10):1035-40. 2011-11-10 [PMID: 22071967] (Flow Cytometry, Human)	Flow Cytometry	Human
Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA Identification of human NK17/NK1 cells. PLoS ONE, 2011-10-21;6(10):e26780. 2011-10-21 [PMID: 22039549] (Flow Cytometry, Human)	Flow Cytometry	Human
Luyan Liu, Satoshi Okada, Xiao-Fei Kong, Alexandra Y. Kreins, Sophie Cypowyj, Avinash Abhyankar et al. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis Journal of Experimental Medicine 8/1/2011 [PMID: 21727188]
Alisa A, Boswell S, Pathan AA, Ayaru L, Williams R, Behboudi S Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells. J. Immunol., 2008-04-01;180(7):5109-17. 2008-04-01 [PMID: 18354237] (Flow Cytometry, Human)	Flow Cytometry	Human
Markovic SN, Nevala WK, Uhl CB, Celis E, McKean DJ A reproducible method for the enumeration of functional (cytokine producing) versus non-functional peptide-specific cytotoxic T lymphocytes in human peripheral blood. Clin. Exp. Immunol., 2006-09-01;145(3):438-47. 2006-09-01 [PMID: 16907911] (Flow Cytometry, Human)	Flow Cytometry	Human
Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression. Am. J. Pathol., 2004-02-01;164(2):409-17. 2004-02-01 [PMID: 14742247] (ICC, IHC-P, Human)	ICC, IHC-P	Human
Show All 19 Publications. Collapse Publications.

Array IC285P

• IFN-gamma Antibodies
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• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes