IFN-gamma Antibody (25718) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma, IFNG), also known as type II or Immune Interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa molecular weight variably glycosylated subunits. Glycosylation of IFN-gamma at sites Asn25 and Asn97 is critical for protease resistance. It shares 90% amino acid (aa) sequence identity with rhesus IFN-gamma, 59-64% with bovine, canine, equine, feline, and porcine IFN‑ gamma, and 37-43% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human,  Human.

We have publications tested in 9 applications: Differentiation, ELISA Detection, Flow Cytometry, Functional Assay, IHC, IHC-Fr, Luminex (Detection), Neutralization, Stimulation.

Showing Publications 1 - 10 of 45. Show All 45 Publications. Collapse Publications.

Publications using MAB285	Applications	Species
Law, C;Wacleche, VS;Cao, Y;Pillai, A;Sowerby, J;Hancock, B;Horisberger, A;Bracero, S;Skidanova, V;Li, Z;Adejoorin, I;Dillon, E;Benque, IJ;Nunez, DP;Simmons, DP;Keegan, J;Chen, L;Baker, T;Brohawn, PZ;Al-Mossawi, H;Hao, LY;Jones, B;Rao, N;Qu, Y;Alves, SE;Accelerating Medicines Partnership: RA/SLE Network, ;Jonsson, AH;Shaw, KS;Vleugels, RA;Massarotti, E;Costenbader, KH;Brenner, MB;Lederer, JA;Hultquist, JF;Choi, J;Rao, DA; Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus Nature 2024-07-10 [PMID: 38987586] (Neutralization, Human)	Neutralization	Human
Wu, S;Dai, X;Xia, Y;Zhao, Q;Zhao, H;Shi, Z;Yin, X;Liu, X;Zhang, A;Yao, Z;Zhang, H;Li, Q;Thorne, RF;Zhang, S;Sheng, W;Hu, W;Gu, H; Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome Cell reports 2024-04-12 [PMID: 38615319] (Neutralization, Human)	Neutralization	Human
Aquino, Y;Bisiaux, A;Li, Z;O'Neill, M;Mendoza-Revilla, J;Merkling, SH;Kerner, G;Hasan, M;Libri, V;Bondet, V;Smith, N;de Cevins, C;Ménager, M;Luca, F;Pique-Regi, R;Barba-Spaeth, G;Pietropaoli, S;Schwartz, O;Leroux-Roels, G;Lee, CK;Leung, K;Wu, JT;Peiris, M;Bruzzone, R;Abel, L;Casanova, JL;Valkenburg, SA;Duffy, D;Patin, E;Rotival, M;Quintana-Murci, L; Dissecting human population variation in single-cell responses to SARS-CoV-2 Nature 2023-08-09 [PMID: 37558883] (Luminex (Detection), Human)	Luminex (Detection)	Human
King, LA;Toffoli, EC;Veth, M;Iglesias-Guimarais, V;Slot, MC;Amsen, D;van de Ven, R;Derks, S;Fransen, MF;Tuynman, JB;Riedl, T;Roovers, RC;Adang, AEP;Ruben, JM;Parren, PWHI;de Gruijl, TD;van der Vliet, HJ; A bispecific ?? T-cell engager targeting EGFR activates a potent V?9V?2 T cell-mediated immune response against EGFR-expressing tumors Cancer immunology research 2023-06-27 [PMID: 37368791] (Neutralization, Human)	Neutralization	Human
R Laufer Bri, A Keren, M Bertolini, Y Ullmann, R Paus, A Gilhar Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata Elife, 2023-03-17;12(0):. 2023-03-17 [PMID: 36930216] (Neutralization, Human)	Neutralization	Human
AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Cells, 2022-08-19;11(16):. 2022-08-19 [PMID: 36010663] (Stimulation, Human)	Stimulation	Human
Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie et al. Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip Advanced Science 2022-05-01 [PMID: 35289122]
Jing Li, Lisha Cheng, Haoyu Jia, Chun Liu, Siqi Wang, Yun Liu et al. IFN‐ gamma facilitates liver fibrogenesis by CD161+CD4+ T cells through a regenerative IL‐23/IL‐17 axis in chronic hepatitis B virus infection Clinical & Translational Immunology 2021-11-02 [PMID: 34754450]
N Smith, P Goncalves, B Charbit, L Grzelak, M Beretta, C Planchais, T Bruel, V Rouilly, V Bondet, J Hadjadj, N Yatim, H Pere, SH Merkling, A Ghozlane, S Kernéis, F Rieux-Lauc, B Terrier, O Schwartz, H Mouquet, D Duffy, JP Di Santo Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection Nature Immunology, 2021-09-01;0(0):. 2021-09-01 [PMID: 34471264] (ELISA Detection, Human)	ELISA Detection	Human
Hu Q, Liao P, Li W et al. Clinical Use of Propranolol Reduces Biomarkers of Proliferation in Gastric Cancer Frontiers in Oncology 4/26/2021 [PMID: 33981600]
Yan-Fang Xing, Jia-Rong Cai, Jun-Jian Qin, Wen-Ying Zhou, Can-Ming Li, Xing Li Expansion of Monocytic Myeloid-Derived Suppressor Cells in Patients Under Hemodialysis Might Lead to Cardiovascular and Cerebrovascular Events Frontiers in Immunology 2021-01-29 [PMID: 33584644]
F Ma, H Hao, X Gao, Y Cai, J Zhou, P Liang, J Lv, Q He, C Shi, D Hu, B Chen, L Zhu, X Xiao, S Li Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway Theranostics, 2020-06-19;10(17):7730-7746. 2020-06-19 [PMID: 32685016] (Neutralization, Human)	Neutralization	Human
Valentin Haug, Branislav Kollar, Sotirios Tasigiorgos, Yori Endo, Martin Kauke, Ali-Farid Safi et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours Transplantation 2020-09-01 [PMID: 32168040]
K Schilbach, C Welker, N Krickeberg, C Kai beta er, S Schleicher, H Hashimoto In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated gammadelta T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells Cancers (Basel), 2020-01-04;12(1):. 2020-01-04 [PMID: 31947966] (Neutralization, Human)	Neutralization	Human
PA Szabo, HM Levitin, M Miron, ME Snyder, T Senda, J Yuan, YL Cheng, EC Bush, P Dogra, P Thapa, DL Farber, PA Sims Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease Nat Commun, 2019-10-17;10(1):4706. 2019-10-17 [PMID: 31624246] (Neutralization, Human)	Neutralization	Human
Paramita Baruah, Jessica Bullenkamp, Philip O. G. Wilson, Michael Lee, Juan Carlos Kaski, Ingrid E. Dumitriu TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2 Frontiers in Immunology 2019-07-16 [PMID: 31379843]
Henna Kallionpää, Juhi Somani, Soile Tuomela, Ubaid Ullah, Rafael de Albuquerque, Tapio Lönnberg et al. Early Detection of Peripheral Blood Cell Signature in Children Developing beta -Cell Autoimmunity at a Young Age Diabetes 2019-10-01 [PMID: 31311800]
Amaro Nunes Duarte-Neto, Julio Croda, Carla Pagliari, Francisco Garcia Soriano, Antonio Carlos Nicodemo, Maria Irma Seixas Duarte Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock Frontiers in Immunology 2019-04-30 [PMID: 31114579]
Michela Frascoli, Lacy Coniglio, Russell Witt, Cerine Jeanty, Shannon Fleck-Derderian, Dana E. Myers et al. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-gamma and TNF-alpha Science Translational Medicine 2018-04-25 [PMID: 29695455]
F Zhang, G Liu, D Li, C Wei, J Hao DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway J. Immunol., 2018-01-29;0(0):. 2018-01-29 [PMID: 29378913] (Functional Assay, Human)	Functional Assay	Human
Y Liu, L Qu, Y Liu, B Roizman, GG Zhou PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2 Proc. Natl. Acad. Sci. U.S.A., 2017-07-31;0(0):. 2017-07-31 [PMID: 28760986] (Neutralization, Human)	Neutralization	Human
MS Longhi, M Vuerich, A Kalbasi, JE Kenison, A Yeste, E Csizmadia, B Vaughn, L Feldbrugge, S Mitsuhashi, B Wegiel, L Otterbein, A Moss, FJ Quintana, SC Robson Bilirubin suppresses Th17 immunity in colitis by upregulating CD39 JCI Insight, 2017-05-04;2(9):. 2017-05-04 [PMID: 28469075] (Neutralization, Human)	Neutralization	Human
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion J Immunol, 2016-08-01;0(0):. 2016-08-01 [PMID: 27481843] (IHC-Fr, Human)	IHC-Fr	Human
Modulation of Stat-1 in Human Macrophages Infected with Different Species of Intracellular Pathogenic Bacteria J Immunol Res, 2016-06-29;2016(0):5086928. 2016-06-29 [PMID: 27437406] (Neutralization, Human)	Neutralization	Human
AS Arterbery, A Osafo-Addo, Y Avitzur, M Ciarleglio, Y Deng, SJ Lobritto, M Martinez, DA Hafler, M Kleinewiet, UD Ekong Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells J. Immunol., 2016-04-18;196(10):4040-51. 2016-04-18 [PMID: 27183637] (Flow Cytometry, Human)	Flow Cytometry	Human
Fudi Zhong, Nan Zhou, Kang Wu, Yubiao Guo, Weiping Tan, Hong Zhang et al. A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes Nucleic Acids Research 2015-12-02 [PMID: 26405199]
Ranzani , Valeria, Rossetti , Grazisa, Panzeri , Ilaria, Arrigoni , Alberto, Bonnal , Raoul J, Curti , Serena, Gruarin , Paola, Provasi , Elena, Sugliano , Elisa, Marconi , Maurizio, De Francesco , Raffaele, Geginat , Jens, Bodega , Beatrice, Abrignani , Sergio, Pagani , Massimil The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol, 2015-01-26;16(3):318-25. 2015-01-26 [PMID: 25621826] (Neutralization, Human)	Neutralization	Human
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE, 2014-05-02;9(5):e96695. 2014-05-02 [PMID: 24792400] (Neutralization, Human)	Neutralization	Human
Erik M. Alcantar-Orozco, Hannah Gornall, Vania Baldan, Robert E. Hawkins, David E. Gilham Potential Limitations of the NSG Humanized Mouse as a Model System to Optimize Engineered Human T cell Therapy for Cancer Human Gene Therapy Methods 2013-10-01 [PMID: 23931270]
Jacqueline K Flynn, Gregory J Dore, Margaret Hellard, Barbara Yeung, William D Rawlinson, Peter A White et al. Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment Journal of Gastroenterology and Hepatology 2013-11-01 [PMID: 23663030]
Vera Luiza Capelozzi, Edwin Roger Parra, Manoel Ximenes, Ricardo Helbert Bammann, Carmen Silvia Valente Barbas, Marid Irmd Seixas Duarte Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine-origin influenza type A/H1N1 and acute respiratory failure Clinics (Sao Paulo) 2010-12-01 [PMID: 21340209]
Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol., 2010-05-02;11(6):527-34. 2010-05-02 [PMID: 20431622] (Neutralization, Human)	Neutralization	Human
A T R-Viso, M I S Duarte, C Pagliari, E R Fernandes, R A Brasil, G Benard et al. Tissue and serum immune response in chronic hepatitis C with mild histological lesions Memórias do Instituto Oswaldo Cruz 2010-02-01 [PMID: 20209325]
Allison B. Reiss, Kamran Anwar, Joan T. Merrill, Edwin S. L. Chan, Nahel W. Awadallah, Bruce N. Cronstein et al. Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease Rheumatology International 2010-03-01 [PMID: 19547978]
Chang HC, Han L, Goswami R, Nguyen ET, Pelloso D, Robertson MJ, Kaplan MH Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood, 2009-04-09;113(23):5887-90. 2009-04-09 [PMID: 19359411] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest., 2007-12-01;117(12):3868-3878. 2007-12-01 [PMID: 18060034] (Neutralization, Human)	Neutralization	Human
Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp. Hematol., 2006-10-01;34(10):1312-22. 2006-10-01 [PMID: 16982324] (Neutralization, Human)	Neutralization	Human
Ebert EC, Mehta V Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 2006-08-17;241(1):7-13. 2006-08-17 [PMID: 16914126] (Neutralization, Human)	Neutralization	Human
Methe H, Wiegand D, Welsch U, Meiser B, Nabauer M, Koglin J Peripheral expansion of circulating T-helper 1 cells predicts coronary endothelial dysfunction after cardiac transplantation. J. Heart Lung Transplant., 2005-07-01;24(7):833-40. 2005-07-01 [PMID: 15982610] (IHC, Human)	IHC	Human
Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J. Immunol., 2004-07-15;173(2):1463-76. 2004-07-15 [PMID: 15240743] (Neutralization, Human)	Neutralization	Human
Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB Reprogramming of IL-10 activity and signaling by IFN-gamma. J. Immunol., 2003-11-15;171(10):5034-41. 2003-11-15 [PMID: 14607900] (Neutralization, Human)	Neutralization	Human
Durali D, de Goer de Herve MG, Giron-Michel J, Azzarone B, Delfraissy JF, Taoufik Y In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment. Blood, 2003-07-31;102(12):4084-9. 2003-07-31 [PMID: 12893768] (Neutralization, Human)	Neutralization	Human
Wolk K, Kunz S, Asadullah K, Sabat R Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol., 2002-06-01;168(11):5397-402. 2002-06-01 [PMID: 12023331] (Functional Assay, Human)	Functional Assay	Human
Ong PY, Hamid QA, Travers JB, Strickland I, Al Kerithy M, Boguniewicz M, Leung DY Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. J. Immunol., 2002-01-01;168(1):505-10. 2002-01-01 [PMID: 11751999] (Neutralization, Human)	Neutralization	Human
Laurent Brossay, Mariacristina Chioda, Nicolas Burdin, Yasuhiko Koezuka, Giulia Casorati, Paolo Dellabona et al. CD1d-mediated Recognition of an alpha -Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution J. Exp. Med 1998-10-19 [PMID: 9782129]
Show All 45 Publications. Collapse Publications.

Array MAB285

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes