IFN-beta Antibody - BSA Free

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: IF/IHC, IHC-Fr, IHC-P, Immunohistochemistry.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NBP1-77288	Applications	Species
Dharshika C, Gonzales J, Chow A et al. Stimulator of interferon genes (STING) expression in the enteric nervous system and contributions of glial STING in disease Neurogastroenterology & Motility 2023-02-27 (Immunohistochemistry)	Immunohistochemistry
Kevin Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Ching-Han Hu, Pei-Chen Yang, Hsin-Yu Chang, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao DNMT1 constrains IFN beta -mediated anti-tumor immunity and PD-L1 expression to reduce the efficacy of radiotherapy and immunotherapy Oncoimmunology 2021-10-21 [PMID: 38283033]
Jana A, Wang X, Leasure JW et al. Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease Scientific reports 2022-10-01 [PMID: 36182964] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Stolberg-Stolberg J, Boettcher A, Sambale M et al. Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis Cell death & disease 2022-03-11 [PMID: 35277480] (IF/IHC, Mouse)	IF/IHC	Mouse
Liu J, Lao L, Chen J et al. The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer Nat Cancer 2022-02-05 [PMID: 35122000]
Mariottoni P, Jiang SW, Prestwood CA et al. Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa Frontiers in Medicine 2021-08-24 [PMID: 34504848] (Immunohistochemistry)	Immunohistochemistry
Kang NX, Zou Y, Liang QH Et al. Anemoside B4 inhibits enterovirus 71 propagation in mice through upregulating 14-3-3 expression and type I interferon responses Acta pharmacologica Sinica 2021-07-28 [PMID: 34321612]
Skopelja-Gardner S, An J, Tai J et al. The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent Sci Rep 2020-05-13 [PMID: 32404939] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Satoh T,Wada R,Yajima N et al. Tumor Microenvironment and RIG-I Signaling Molecules in Epstein Barr Virus-Positive and -Negative Classical Hodgkin Lymphoma of the Elderly J Clin Exp Hematop. 2014-06-19 [PMID: 24942949] (IHC-P, Human) Details: Interferon beta antibody used for IHC-P on human Classical Hodgkin Lymphoma/CHL cases - antigen retreival with Tris/EDTA buffer pH9.0 125C for 3 min, blocking with Background Sniper, Primary 1:500 dilution ON 4C, endogenous peroxidase blocking with 1% H2O2 in methanol, detection with MACH3 Rabbit HRP Polymer Detection -EnzMet vizualization. Fig. 3, last panel - double immunostaining of IFN beta (black ) with CD30 (red - Hodgkin and Reed Sternberg cells) in Epstein-Barr virus /EBV positive and negative CHL cases.	IHC-P	Human
Kock M, Mostert J, De Keyser J et al. Interferon-beta treatment and the natural history of relapsing-remitting multiple sclerosis. Ann. Neurol. 2007-01-01 [PMID: 17702024]
Colonna M. TLR pathways and IFN-regulatory factors: to each its own. Eur. J. Immunol. 37:306-9. 2007-01-01 [PMID: 17273997]
Gresser I. Wherefore interferon? . J. Leuk. Biol. 61:567-74. 1997-01-01 [PMID: 9129205]
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	ICC	Mouse	04/07/2023	View Summary Application Immunocytochemistry Sample Tested N9 cell line Species Mouse Lot 8813-2004T

Array NBP1-77288

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta Proteins and Enzymes
• IFN-beta ELISAs