ICAM-5 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Intercellular adhesion molecule-5 (ICAM-5), also known as telencephalin, is an integral membrane glycoprotein expressed in neurons of mammalian telencephalons. ICAM-5 is a member of the immunoglobulin superfamily and shares 38-55% amino acid homology with other ICAMs. Structurally, ICAM-5 contains nine Ig domains that included 15 N-glycosylation sites, a single transmembrane region, and C-terminal cytoplasmic tail (1). As with other members of the ICAM family, ICAM-5 has been shown to be involved in cellular adhesion. ICAM-5 binds to the leukocyte integrin LFA-1 (CD11a/CD18) via its first NH2-terminal Ig domain. The ability of
ICAM‑5 to bind LFA-1 suggests that ICAM-5 may play an important role in immune responses in the central nervous system (2). Additionally, ICAM-5 has been found to promote homophilic binding via binding of the first Ig domain to Ig domains 4-5. Homophilic adhesion activity of ICAM-5 is regulated by a monomer/tetramer transition. ICAM-5 expression temporally parallels the onset of dendritic elongation and synaptogenesis during the postnatal period suggesting that ICAM-5 may provide a brain segment-specific cue for synaptogenesis or dendrite-dendrite interaction (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: Immunoprecipitation, Western Blot.

Showing Publications 1 - 5 of 5.

Publications using AF1173	Applications	Species
Alison M. Hixon, Penny Clarke, Kenneth L. Tyler Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid Journal of Virology 8/15/2019 [PMID: 31167912]
Harold K. Shearin, Casey D. Quinn, Robert D. Mackin, Ian S. Macdonald, R. Steven Stowers t-GRASP, a targeted GRASP for assessing neuronal connectivity Journal of Neuroscience Methods 8/1/2018 [PMID: 29792886]
Niedringhaus M, Chen X, Dzakpasu R, Conant K MMPs and soluble ICAM-5 increase neuronal excitability within in vitro networks of hippocampal neurons. PLoS ONE, 2012-08-13;7(8):e42631. 2012-08-13 [PMID: 22912716] (Western Blot, Rat)	Western Blot	Rat
Conant K, Lonskaya I, Szklarczyk A, Krall C, Steiner J, Maguire-Zeiss K, Lim ST Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5. J. Neurochem., 2011-01-19;118(4):521-32. 2011-01-19 [PMID: 21166806] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
Conant K, Wang Y, Szklarczyk A, Dudak A, Mattson MP, Lim ST Matrix metalloproteinase-dependent shedding of intercellular adhesion molecule-5 occurs with long-term potentiation. Neuroscience, 2010-01-04;166(2):508-21. 2010-01-04 [PMID: 20045450] (Western Blot, Rat)	Western Blot	Rat

Array AF1173

• ICAM-5 Antibodies
• ICAM-5 Proteins
• ICAM-5 Proteins and Enzymes
• ICAM-5 ELISA