Human Total ErbB3/Her3 DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ErbB3, also called Her3 (human epidermal growth factor receptor 3) in humans, is a type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB3 binds neuregulins NRG1 and NRG2, but lacks a working kinase domain; heterodimerization with another ErbB receptor is required for signaling. ErbB3 is important in development of Schwann cells, neural crest cells, heart valves and the sympathetic nervous system. When expressed with ErbB2 in breast, skin, ovary and gastrointestinal tumors, ErbB3 is a potent mitogen.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 4 of 4.

Publications using DYC234-2	Applications	Species
Yamashita-Kashima Y, Iijima S, Yorozu K, Furugaki K, Kurasawa M, Ohta M, Fujimoto-Ouchi K Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models. Clin. Cancer Res., 2011-06-23;17(15):5060-70. 2011-06-23 [PMID: 21700765] (Human)		Human
Hickinson DM, Marshall GB, Beran GJ Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib. Clin Transl Sci, 2009-06-01;2(3):183-92. 2009-06-01 [PMID: 20443891] (Human)		Human
Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoel MJ, Fartoux L, Venot C, Bladt F, Housset C, Rosmorduc O Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin. Cancer Res., 2009-08-25;15(17):5445-56. 2009-08-25 [PMID: 19706799] (Human)		Human
Sarup J, Jin P, Turin L, Bai X, Beryt M, Brdlik C, Higaki JN, Jorgensen B, Lau FW, Lindley P, Liu J, Ni I, Rozzelle J, Kumari R, Watson SA, Zhang J, Shepard HM Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. Mol. Cancer Ther., 2008-10-01;7(10):3223-36. 2008-10-01 [PMID: 18852126] (Human)		Human

Array DYC234-2

• ErbB3/Her3 Antibodies
• ErbB3/Her3 Antibody Pairs
• ErbB3/Her3 ELISA Kit
• ErbB3/Her3 Lysates
• ErbB3/Her3 Proteins
• ErbB3/Her3 Proteins and Enzymes
• ErbB3/Her3 ELISAs