Human Thrombomodulin/BDCA-3 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thrombomodulin (TM), also known as CD141 and BDCA3, is a transmembrane expressed on vascular endothelial cells (EC), arterial smooth muscle cells, monocytes, and macrophages. It binds Thrombin and enhances the Thrombin-mediated activation of the anti-coagulant Protein C and the anti-fibrinolytic TAFI/Carboxypeptidase B2. Thrombomodulin also inhibits the ability of Thrombin to activate several pro-coagulant proteins (e.g. Fibrinogen, Factor V, Factor XIII, PAR-1). Thrombomodulin exerts multiple anti-inflammatory effects and reduces the severity of disease involving chronic inflammation. In cancer, Thrombomodulin suppresses tumor angiogenesis, growth, and epithelial-mesenchymal transition. Soluble fragments of Thrombomodulin are elevated in the serum, urine, and synovial fluid during coagulation disorders, inflammation, and organ failure.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 8 of 8.

Publications using DY3947	Applications	Species
J Budzianows, J Hiczkiewic, K ?ojewska, E Kawka, R Rutkowski, K Korybalska Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight Journal of Clinical Medicine, 2021-06-18;10(12):. 2021-06-18 [PMID: 34207297] (Human)		Human
V Chaban, ER Nakstad, H Stær-Jense, C Schjalm, I Seljeflot, J Vaage, C Lundqvist, JŠ Benth, K Sunde, TE Mollnes, GØ Andersen, SE Pischke Complement activation is associated with poor outcome after out-of-hospital cardiac arrest Resuscitation, 2021-06-11;0(0):. 2021-06-11 [PMID: 34126135] (Human)		Human
MP Ward, FA Saadeh, SA O'Toole, JJ O'Leary, N Gleeson, LA Norris Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway Thrombosis Research, 2021-01-26;200(0):91-98. 2021-01-26 [PMID: 33571724] (Human)		Human
K Lashkari, GC Teague, U Beattie, J Betts, S Kumar, MM McLaughlin, FJ López Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration PLoS ONE, 2020-08-07;15(8):e0236283. 2020-08-07 [PMID: 32764794] (Human)		Human
A Merz, U Germing, G Kobbe, J Kaivers, A Jauch, A Radujkovic, M Hummel, A Benner, M Merz, P Dreger, T Luft EASIX for prediction of survival in lower-risk myelodysplastic syndromes Blood Cancer J, 2019-11-11;9(11):85. 2019-11-11 [PMID: 31712595] (Human)		Human
A Radujkovic, H Dai, L Kordelas, D Beelen, SP Rachakonda, C Müller-Tid, R Kumar, P Dreger, T Luft Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation Haematologica, 2018-12-04;0(0):. 2018-12-04 [PMID: 30514796] (Human)		Human
G Aguilar-Ma, B Pesch, ES Calderón-A, K Burek, C Jiménez-Ra, CA Juárez-Pér, MD Ochoa-Vázq, L Torre-Bous, LC Acosta-Saa, I Sada-Ovall, J García-Fig, I Alvarado-C, P Castillo-G, AR Báez-Salda, JR Pérez-Padi, J Osnaya-Juá, RM Rivera-Ros, EM García-Baz, YL Bautista-A, E Lazcano-He, DA Munguía-Ca, LM Argote-Gre, D Taeger, DG Weber, S Casjens, I Raiko, T Brüning, G Johnen Biomarkers for Predicting Malignant Pleural Mesothelioma in a Mexican Population Int J Med Sci, 2018-06-04;15(9):883-891. 2018-06-04 [PMID: 30008600] (Human)		Human
Martin F, McLoughlin A, Rochfort K, Davenport C, Murphy R, Cummins P Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain. PLoS ONE, 2014-09-19;9(9):e108254. 2014-09-19 [PMID: 25238231] (Human)		Human

Array DY3947

• Thrombomodulin/BDCA-3 Antibodies
• Thrombomodulin/BDCA-3 ELISA Kits
• Thrombomodulin/BDCA-3 Protein
• Thrombomodulin/BDCA-3 ELISAs
• Thrombomodulin/BDCA-3 Proteins and Enzymes