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Human TGF-beta 1 DuoSet ELISA, 15 Plate

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Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

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Human TGF-beta 1 DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
TGFB1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY240.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TGF-beta 1 DuoSet ELISA, 15 Plate

  • CEDLAP
  • DPD1
  • latency-associated peptide
  • TGF beta
  • TGF beta1
  • TGFB
  • TGFB1
  • TGF-beta 1 protein
  • TGFbeta 1
  • TGF-beta 1
  • TGFbeta
  • TGF-beta-1
  • transforming growth factor beta-1
  • transforming growth factor, beta 1

Background

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

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Publications for TGF-beta 1 (DY240)(191)

We have publications tested in 10 confirmed species: Human, Mouse, Rat, Bovine, Canine, Equine, Feline, Guinea Pig, N/A, Rabbit.


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Human
(169)
Mouse
(6)
Rat
(2)
Bovine
(3)
Canine
(1)
Equine
(3)
Feline
(1)
Guinea Pig
(2)
N/A
(2)
Rabbit
(2)
All Species
Showing Publications 1 - 10 of 191. Show All 191 Publications.
Publications using DY240 Applications Species
Malek, E;Rana, PS;Swamydas, M;Daunov, M;Miyagi, M;Murphy, E;Ignatz-Hoover, JJ;Metheny, L;Kim, SJ;Driscoll, JJ; The TGF? type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial Nature communications 2024-08-27 [PMID: 39191755] (Human) Human
Yun, YI;Ko, JH;Ryu, JS;Kim, S;Jeon, HS;Kim, N;Kim, MK;Oh, JY; Toxicity and efficacy of type I interferons on the ocular surface: in vitro, animal, and clinical studies The ocular surface 2024-07-11 [PMID: 39002721] (Human) Human
Cho, HY;Lee, JE;Park, KH;Choi, BY;Lee, MJ;Jeong, DE;Shin, S; Identification and characterization of plasma proteins associated with intra-amniotic inflammation and/or infection in women with preterm labor. Scientific reports 2024-06-25 [PMID: 38918423] (Human) Human
Ferrer, P;Berry, AA;Bucsan, AN;Prajapati, SK;Krishnan, K;Barbeau, MC;Rickert, DM;Guerrero, SM;Usui, M;Abebe, Y;Patil, A;Chakravarty, S;Billingsley, PF;Pa'ahana-Brown, F;Strauss, K;Shrestha, B;Nomicos, E;Deye, GA;Sim, BKL;Hoffman, SL;Williamson, KC;Lyke, KE; Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms Nature communications 2024-06-18 [PMID: 38890271] (Human) Human
Egawa, Y;Higuchi, T;Hashida, Y;Ueno, K;Kojima, K;Daibata, M; Novel paired CD13-negative (MT-50.1) and CD13-positive (MT-50.4) HTLV-1-infected T-cell lines with differential regulatory T cell-like activity Scientific reports 2024-05-31 [PMID: 38822041] (Human) Human
Louault, K;Blavier, L;Lee, MH;Kennedy, RJ;Fernandez, GE;Pawel, BR;Asgharzadeh, S;DeClerck, YA; Nuclear factor-?B activation by transforming growth factor-?1 drives tumour microenvironment-mediated drug resistance in neuroblastoma British journal of cancer 2024-05-28 [PMID: 38806726] (Human) Human
Zhang, Y;Jiang, H;Dong, M;Min, J;He, X;Tan, Y;Liu, F;Chen, M;Chen, X;Yin, Q;Zheng, L;Shao, Y;Li, X;Chen, H; Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation Cell reports 2024-05-28 [PMID: 38733581] (Human) Human
Camarena, V;Williams, MM;Morales, AA;Zafeer, MF;Kilic, OV;Kamiar, A;Abad, C;Rasmussen, MA;Briski, LM;Peart, L;Bademci, G;Barbouth, DS;Smithson, S;Wang, G;Shehadeh, LA;Walz, K;Tekin, M; ADAMTSL2 mutations determine the phenotypic severity in Geleophysic Dysplasia JCI insight 2024-02-01 [PMID: 38300707] (Mouse) Mouse
Miguel-Pastor, L;Satué, K;Chicharro, D;Damiá, E;Cuervo, B;Torres-Torrillas, M;Martins, E;Velasco-Martínez, MG;Carrillo, JM;Sopena, JJ;Cerón, JJ;Rubio, M; Characterization of platelet rich plasma in feline immunodeficiency virus-infected cats: Cell, and PDGF-BB and TGF-beta 1 growth factor analysis Research in veterinary science 2024-01-06 [PMID: 38218061] (Feline) Feline
Noyola-Martínez, N;Chirinos, M;Ramírez-Camacho, I;Escamilla-Bucio, JE;García-Olivares, M;Aragón-Hernández, JP;Segovia-Mendoza, M;Halhali, A;Barrera, D; Effects of calcitriol upon TGF-?s and their receptors in trophoblast cells Journal of reproductive immunology 2023-12-10 [PMID: 38141515] (Human) Human
Show All 191 Publications.

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Additional TGF-beta 1 Products

Blogs on TGF-beta 1.

TGF-beta 1 - a versatile signaling molecule with roles in development and disease
The transforming growth factor-beta (TGF-beta) family consists of a wide variety of signaling proteins with roles in development. TGF-beta signaling controls growth, differentiation, and immune responses and is often misregulated in cancer. TGF-beta ...  Read full blog post.

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Bioinformatics

Gene Symbol TGFB1