Human Serpin F1/PEDF DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

We have publications tested in 3 confirmed species: Human, Mouse, Xenograft.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using DY1177-05	Applications	Species
Basu, B;Karwatka, M;China, B;McKibbin, M;Khan, K;Inglehearn, CF;Ladbury, JE;Johnson, CA; Glycogen myophosphorylase loss causes increased dependence on glucose in iPSC-derived retinal pigment epithelium The Journal of biological chemistry 2024-07-13 [PMID: 39009342] (Human)		Human
Hiniduma, K;Bhalerao, KS;De Silva, PIT;Chen, T;Rusling, JF; Design and Fabrication of a 3D-Printed Microfluidic Immunoarray for Ultrasensitive Multiplexed Protein Detection Micromachines 2023-11-30 [PMID: 38138356] (Human)		Human
L Chen, ND Perera, AJ Karoukis, KL Feathers, RR Ali, DA Thompson, AT Fahim Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells Scientific Reports, 2022-07-26;12(1):12694. 2022-07-26 [PMID: 35882889] (Human)		Human
MC Ebeling, CR Fisher, RJ Kapphahn, MR Stahl, S Shen, J Qu, SR Montezuma, DA Ferrington Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration Cells, 2022-06-30;11(13):. 2022-06-30 [PMID: 35805159] (Human)		Human
A Riley, H Jones, J England, D Kuvshinov, V Green, J Greenman Identification of soluble tissue-derived biomarkers from human thyroid tissue explants maintained on a microfluidic device Oncology Letters, 2021-09-13;22(5):780. 2021-09-13 [PMID: 34594421] (Human)		Human
MC Ebeling, Z Geng, RJ Kapphahn, H Roehrich, SR Montezuma, JR Dutton, DA Ferrington Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration Cells, 2021-04-02;10(4):. 2021-04-02 [PMID: 33918210] (Human)		Human
X Bao, J Zeng, H Huang, C Ma, L Wang, F Wang, X Liao, X Song Cancer-Targeted PEDF-DNA Therapy for Metastatic Colorectal Cancer Int J Pharm, 2019-12-29;0(0):118999. 2019-12-29 [PMID: 31893541] (Mouse)		Mouse
H Wang, Y Yang, M Yang, X Li, J Tan, Y Wu, Y Zhang, Y Li, B Hu, S Deng, F Yang, S Gao, H Li, Z Yang, H Chen, W Cai Pigment Epithelial-Derived Factor Deficiency Accelerates Atherosclerosis Development via Promoting Endothelial Fatty Acid Uptake in Mice With Hyperlipidemia J Am Heart Assoc, 2019-11-12;8(22):e013028. 2019-11-12 [PMID: 31711388] (Human)		Human
C Li, Z Huang, L Zhu, X Yu, T Gao, J Feng, H Hong, H Yin, T Zhou, W Qi, Z Yang, C Liu, X Yang, G Gao The contrary intracellular and extracellular functions of PEDF in HCC development Cell Death Dis, 2019-10-03;10(10):742. 2019-10-03 [PMID: 31582735] (Xenograft)		Xenograft
G Sagaradze, O Grigorieva, P Nimiritsky, N Basalova, N Kalinina, Z Akopyan, A Efimenko Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation Int J Mol Sci, 2019-04-03;20(7):. 2019-04-03 [PMID: 30987106] (Human)		Human
Y Simonin, N Erkilic, K Damodar, M Clé, C Desmetz, K Bolloré, M Taleb, S Torriano, J Barthelemy, G Dubois, AD Lajoix, V Foulongne, E Tuaillon, P Van de Per, V Kalatzis, S Salinas Zika virus induces strong inflammatory responses and impairs homeostasis and function of the human retinal pigment epithelium EBioMedicine, 2018-12-20;0(0):. 2018-12-20 [PMID: 30579862] (Human)		Human
AD Marmorstei, AA Johnson, LA Bachman, C Andrews-Pf, T Knudsen, BJ Gilles, M Hill, JK Gandhi, LY Marmorstei, JS Pulido Mutant Best1 Expression and Impaired Phagocytosis in an iPSC Model of Autosomal Recessive Bestrophinopathy Sci Rep, 2018-03-14;8(1):4487. 2018-03-14 [PMID: 29540715] (Human)		Human
H Zhang, Y Xu, H Yue, C Wang, J Gu, J He, W Fu, W Hu, Z Zhang Novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta Int. J. Mol. Med., 2018-03-07;0(0):. 2018-03-07 [PMID: 29512769] (Human)		Human
M Eslani, I Putra, X Shen, J Hamouie, N Afsharkham, S Besharat, MI Rosenblatt, R Dana, P Hematti, AR Djalilian Corneal Mesenchymal Stromal Cells Are Directly Antiangiogenic via PEDF and sFLT-1 Invest. Ophthalmol. Vis. Sci., 2017-10-01;58(12):5507-5517. 2017-10-01 [PMID: 29075761] (Human)		Human
DA Ferrington, MC Ebeling, RJ Kapphahn, MR Terluk, CR Fisher, JR Polanco, H Roehrich, MM Leary, Z Geng, JR Dutton, SR Montezuma Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration Redox Biol, 2017-06-01;13(0):255-265. 2017-06-01 [PMID: 28600982] (Human)		Human
Z Geng, PJ Walsh, V Truong, C Hill, M Ebeling, RJ Kapphahn, SR Montezuma, C Yuan, H Roehrich, DA Ferrington, JR Dutton Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration PLoS ONE, 2017-03-10;12(3):e0173575. 2017-03-10 [PMID: 28282420] (Human)		Human
W Shen, B Yau, SR Lee, L Zhu, M Yam, MC Gillies Effects of Ranibizumab and Aflibercept on Human M�ller Cells and Photoreceptors under Stress Conditions Int J Mol Sci, 2017-03-01;18(3):. 2017-03-01 [PMID: 28257068] (Human)		Human
Promising Nanocarriers for PEDF Gene Targeting Delivery to Cervical Cancer Cells Mediated by the Over-expressing FR? Sci Rep, 2016-08-31;6(0):32427. 2016-08-31 [PMID: 27576898] (Mouse)		Mouse
McHugh K, Tao S, Saint-Geniez M Porous poly(epsilon-caprolactone) scaffolds for retinal pigment epithelium transplantation. Invest Ophthalmol Vis Sci, 2014-03-25;55(3):1754-62. 2014-03-25 [PMID: 24550370] (Human)		Human
Show All 19 Publications. Collapse Publications.

Array DY1177-05

• Serpin F1/PEDF Antibodies
• Serpin F1/PEDF ELISA Kits
• Serpin F1/PEDF Lysate
• Serpin F1/PEDF Proteins
• Serpin F1/PEDF ELISA
• Serpin F1/PEDF Proteins and Enzymes