Human PDGF-AA DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The platelet-derived growth factor (PDGF) family of disulfide-linked dimeric proteins consists of four homodimeric proteins, PDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD, and one heterodimeric protein, PDGF-AB. Members of this protein family act mainly on connective tissue. The dimeric isoforms of PDGF are expressed by different cell types and at different times during embryonic development. All PDGF isoforms are synthesized as inactive precursors and are processed to active forms that contain a PDGF/VEGF cysteine knot domain. Only PDGF-C and PDGF-D, also named spinal cord-derived growth factors SCDGF and SCDGF-B, also contain an N-terminal CUB domain. Mature PDGF dimers bind and induce the homo- or hetero-dimerization of two receptor tyrosine kinases (PDGF R alpha and R beta).

We have publications tested in 2 confirmed species: Human, Xenograft.

Showing Publications 1 - 10 of 10.

Publications using DY221	Applications	Species
Berlin, F;Mogren, S;Ly, C;Ramu, S;Hvidtfeldt, M;Uller, L;Porsbjerg, C;Andersson, CK; Mast Cell Tryptase Promotes Airway Remodeling by Inducing Anti-Apoptotic and Cell Growth Properties in Human Alveolar and Bronchial Epithelial Cells Cells 2023-05-22 [PMID: 37408273] (Human)		Human
R Haldar, LS Berger, E Rossenne, A Radin, A Eckerling, E Sandbank, EK Sloan, SW Cole, S Ben-Eliyah Perioperative escape from dormancy of spontaneous micro-metastases: A role for malignant secretion of IL-6, IL-8, and VEGF, through adrenergic and prostaglandin signaling Brain, Behavior, and Immunity, 2023-01-13;0(0):. 2023-01-13 [PMID: 36646396] (Xenograft)		Xenograft
H Weisser, T Göbel, G Melissa Kr, M Krei beta , C Angioni, D Sürün, D Thomas, T Schmid, AK Häfner, AS Kahnt Knock-out of 5-lipoxygenase in overexpressing tumor cells-consequences on gene expression and cellular function Cancer Gene Therapy, 2022-09-16;0(0):. 2022-09-16 [PMID: 36114329] (Human)		Human
P Szpakowski, D Ksiazek-Wi, M Turniak-Ku, I Pacan, A Glabinski Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli Biomedicines, 2022-07-22;10(8):. 2022-07-22 [PMID: 35892669] (Human)		Human
S Ravichandr, G Grubbs, J Tang, Y Lee, C Huang, H Golding, S Khurana Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2-infected individuals reveal unlinked immune signatures Science Advances, 2021-10-13;7(42):eabi6533. 2021-10-13 [PMID: 34644111] (Human)		Human
CM Abreu, MT Cerqueira, RP Pirraco, L Gasperini, RL Reis, AP Marques Rescuing key native traits in cultured dermal papilla cells for human hair regeneration Journal of advanced research, 2020-11-04;30(0):103-112. 2020-11-04 [PMID: 34026290] (Human)		Human
N Casagrande, C Borghese, F Agostini, C Durante, M Mazzucato, A Colombatti, D Aldinucci In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel International Journal of Molecular Sciences, 2021-03-16;22(6):. 2021-03-16 [PMID: 33809553] (Human)		Human
G Ye, Z Xie, H Zeng, P Wang, J Li, G Zheng, S Wang, Q Cao, M Li, W Liu, S Cen, Z Li, Y Wu, Z Ye, H Shen Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis Cell Death Dis, 2020-09-17;11(9):775. 2020-09-17 [PMID: 32943613] (Human)		Human
LH Lin, JS Lin, CC Yang, HW Cheng, KW Chang, CJ Liu Overexpression of Platelet-Derived Growth Factor and Its Receptor Are Correlated with Oral Tumorigenesis and Poor Prognosis in Oral Squamous Cell Carcinoma Int J Mol Sci, 2020-03-29;21(7):. 2020-03-29 [PMID: 32235327] (Human)		Human
CY Chen, SM Wu, YH Lin, HC Chi, SL Lin, CT Yeh, WY Chuang, KH Lin Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer Theranostics, 2019-04-13;9(8):2361-2379. 2019-04-13 [PMID: 31149049] (Human)		Human

Array DY221

• PDGF-AA Antibodies
• PDGF-AA ELISA Kit
• PDGF-AA Proteins
• PDGF-AA ELISA
• PDGF-AA Proteins and Enzymes