Human IL-7 Quantikine HS ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-7 (Interleukin-7) is a cytokine that plays important roles in lymphocyte differentiation, proliferation, and survival. IL-7 is produced by stromal epithelial cells of the thymus, bone marrow, and intestines. It signals through a receptor complex composed of IL-7 R alpha/CD127 and the Common gamma Chain. gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21. IL-7 contributes to the maintenance of all naïve and memory T cells. It is required for optimal T cell-dendritic cell interaction. In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development.

We have publications tested in 6 confirmed species: Human, Primate, Primate - Cebus capucinus (White-headed Capuchin Monkey), Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio cynocephalus (Yellow Baboon).

Showing Publications 1 - 10 of 45. Show All 45 Publications. Collapse Publications.

Publications using HS750	Applications	Species
Chen, S;Nguyen, TD;Lee, KZ;Liu, D; Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies Biotechnology advances 2024-08-19 [PMID: 39168355] (Human)		Human
Y Kitamura, YI Koma, K Tanigawa, S Tsukamoto, Y Azumi, S Miyako, S Urakami, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma Cancers, 2023-01-06;15(2):. 2023-01-06 [PMID: 36672342] (Human)		Human
C Cuéllar, M Rodero, J Pérez-Grie, L Galindo-Re, F Lopez-Chul, C García-Bal, J Carlos And Association between anti-Anisakis simplex antibodies and interleukin-7 levels International immunopharmacology, 2022-08-11;111(0):109134. 2022-08-11 [PMID: 35964412] (Human)		Human
T Sainz, L Diaz, D Rojo, MI Clemente, C Barbas, MJ Gosalbes, N Jimenez-He, L Escosa, S Guillen, JT Ramos, MÁ Muñoz-Fern, ML Navarro, MJ Mellado, S Serrano-Vi Targeting the Gut Microbiota of Vertically HIV-Infected Children to Decrease Inflammation and Immunoactivation: A Pilot Clinical Trial Nutrients, 2022-02-26;14(5):. 2022-02-26 [PMID: 35267967] (Human)		Human
C Bacchus-So, M Fitch, J Symons, M Abdel-Mohs, DB Reeves, R Hoh, M Stone, J Hiatt, P Kim, A Chopra, H Ahn, VA York, DL Cameron, FM Hecht, JN Martin, SA Yukl, S Mallal, PU Cameron, SG Deeks, JT Schiffer, SR Lewin, MK Hellerstei, JM McCune, PW Hunt Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART PloS Pathogens, 2021-01-19;17(1):e1009214. 2021-01-19 [PMID: 33465157] (Human)		Human
J Xun, T Qi, L Zou, Q Tang, Y Shen, J Yang, L Xie, Y Ji, R Zhang, L Liu, J Wang, C Steinhart, Z Wang, Y Tang, W Song, J Sun, J Cheng, X Le, H Wu, X He, R Chen, J Chen, H Lu Mycobacterium tuberculosis co-infection is associated with increased surrogate marker of the HIV reservoir AIDS Res Ther, 2020-10-19;17(1):63. 2020-10-19 [PMID: 33076959] (Human)		Human
Y Yuan, C Zhou, Q Yang, S Ma, X Wang, X Guo, Y Ding, J Tang, Y Zeng, D Li HIV-1 Tat protein inhibits the hematopoietic support function of human bone marrow mesenchymal stem cells Virus Res., 2019-09-12;273(0):197756. 2019-09-12 [PMID: 31521762] (Human)		Human
A Rajamanick, S Munisankar, Y Bhootra, CK Dolla, K Thiruvenga, TB Nutman, S Babu Altered levels of memory T cell subsets and common ?c cytokines in Strongyloides stercoralis infection and partial reversal following anthelmintic treatment PLoS Negl Trop Dis, 2018-05-24;12(5):e0006481. 2018-05-24 [PMID: 29795573] (Human)		Human
J Seyfarth, C Lundtoft, K Förtsch, H Ahlert, J Rosenbauer, C Baechle, M Roden, RW Holl, E Mayatepek, S Kummer, T Meissner, M Jacobsen IL7RA haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes Pediatr Diabetes, 2018-03-13;0(0):. 2018-03-13 [PMID: 29484785] (Human)		Human
C Lundtoft, A Afum-Adjei, J Rimpler, K Harling, N Nausch, M Kohns, E Adankwah, F Lang, L Olbrich, E Mayatepek, E Owusu-Dabo, M Jacobsen Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis PLoS Pathog., 2017-06-05;13(6):e1006425. 2017-06-05 [PMID: 28582466] (Human)		Human
R Ponte, M Rancez, S Figueiredo, J Dutrieux, V Fabre-Mers, B Charmeteau, T Guilbert, JP Routy, R Cheynier, A Couëdel-Co Acute Simian Immunodeficiency Virus Infection Triggers Early and Transient Interleukin-7 Production in the Gut, Leading to Enhanced Local Chemokine Expression and Intestinal Immune Cell Homing Front Immunol, 2017-05-19;8(0):588. 2017-05-19 [PMID: 28579989] (Primate)		Primate
NP Kumar, VV Banurekha, D Nair, S Babu Diminished plasma levels of common ?-chain cytokines in pulmonary tuberculosis and reversal following treatment PLoS ONE, 2017-04-27;12(4):e0176495. 2017-04-27 [PMID: 28448542] (Human)		Human
P Severino, DT Palomino, H Alvarenga, CB Almeida, DC Pasqualim, A Cury, PR Salvalaggi, AL De Vasconc, MC Andrade, T Aloia, S Bromberg, LV Rizzo, FA Rocha, LC Marti Human Lymph Node-Derived Fibroblastic and Double-Negative Reticular Cells Alter Their Chemokines and Cytokines Expression Profile Following Inflammatory Stimuli Front Immunol, 2017-02-14;8(0):141. 2017-02-14 [PMID: 28261205] (Human)		Human
Establishment of IL-7 Expression Reporter Human Cell Lines, and Their Feasibility for High-Throughput Screening of IL-7-Upregulating Chemicals PLoS ONE, 2016-09-02;11(9):e0161899. 2016-09-02 [PMID: 27589392] (Human)		Human
Okoye A, Rohankhedkar M, Konfe A, Abana C, Reyes M, Clock J, Duell D, Sylwester A, Sammader P, Legasse A, Park B, Axthelm M, Nikolich-Zugich J, Picker L Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques. J Immunol, 2015-09-28;195(9):4292-305. 2015-09-28 [PMID: 26416281] (Primate - Macaca mulatta (Rhesus Macaque))		Primate - Macaca mulatta (Rhesus Macaque)
Bazdar D, Kalinowska M, Panigrahi S, Sieg S Recycled IL-7 Can Be Delivered to Neighboring T Cells. J Immunol, 2015-04-13;194(10):4698-704. 2015-04-13 [PMID: 25870237] (Human)		Human
Hannon M, Beguin Y, Ehx G, Servais S, Seidel L, Graux C, Maertens J, Kerre T, Daulne C, De Bock M, Fillet M, Ory A, Willems E, Gothot A, Humblet-Baron S, Baron F Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning. Clin Cancer Res, 2015-03-16;21(14):3131-9. 2015-03-16 [PMID: 25779951] (Human)		Human
Bruel T, Hamimi C, Dereuddre-Bosquet N, Cosma A, Shin S, Corneau A, Versmisse P, Karlsson I, Malleret B, Targat B, Barre-Sinoussi F, Le Grand R, Pancino G, Saez-Cirion A, Vaslin B Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses. J Virol, 2015-01-14;89(7):3542-56. 2015-01-14 [PMID: 25589645] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))		Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Kielsen K, Jordan K, Uhlving H, Pontoppidan P, Shamim Z, Ifversen M, Heilmann C, Nielsen C, Sengelov H, Ryder L, Muller K T cell reconstitution in allogeneic haematopoietic stem cell transplantation: prognostic significance of plasma interleukin-7. Scand J Immunol, 2015-01-01;81(1):72-80. 2015-01-01 [PMID: 25263171] (Human)		Human
Cha L, de Jong E, French M, Fernandez S IFN-alpha exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection. J Immunol, 2014-07-25;193(5):2178-86. 2014-07-25 [PMID: 25063872] (Human)		Human
Le Saout C, Hasley R, Imamichi H, Tcheung L, Hu Z, Luckey M, Park J, Durum S, Smith M, Rupert A, Sneller M, Lane H, Catalfamo M Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS Pathog, 2014-03-06;10(3):e1003976. 2014-03-06 [PMID: 24603698] (Human)		Human
Loubaki L, Hadj-Salem I, Fakhfakh R, Jacques E, Plante S, Boisvert M, Aoudjit F, Chakir J Co-culture of human bronchial fibroblasts and CD4+ T cells increases Th17 cytokine signature. PLoS ONE, 2013-12-05;8(12):e81983. 2013-12-05 [PMID: 24349168] (Human)		Human
Cai , Yu-Jiao, Wang , Wen-Shen, Yang , Yang, Sun , Li-Hua, Teitelbaum , Daniel H, Yang , Hua Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway. PLoS ONE, 2013-03-12;8(3):e58647. 2013-03-12 [PMID: 23554911] (Human)		Human
Zheng M, Zhang Z, Bemis K, Belch A, Pilarski L, Shively J, Kirshner J The systemic cytokine environment is permanently altered in multiple myeloma. PLoS ONE, 2013-03-27;8(3):e58504. 2013-03-27 [PMID: 23544044] (Human)		Human
Decreased systemic IL-7 and soluble IL-7Ralpha in multiple sclerosis patients. Genes Immun, 2012-08-23;13(7):587-92. 2012-08-23 [PMID: 22914435] (Human)		Human
Vassena L, Miao H, Cimbro R, Malnati MS, Cassina G, Proschan MA, Hirsch VM, Lafont BA, Morre M, Fauci AS, Lusso P Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques. PLoS Pathog., 2012-04-12;8(4):e1002636. 2012-04-12 [PMID: 22511868] (Primate - Macaca mulatta (Rhesus Macaque))		Primate - Macaca mulatta (Rhesus Macaque)
Steel C, Nutman TB Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen. PLoS ONE, 2011-04-29;6(4):e19197. 2011-04-29 [PMID: 21559422] (Human)		Human
Thiant S, Labalette M, Trauet J, Coiteux V, de Berranger E, Dessaint JP, Yakoub-Agha I Plasma levels of IL-7 and IL-15 after reduced intensity conditioned allo-SCT and relationship to acute GVHD. Bone Marrow Transplant., 2010-12-06;46(10):1374-81. 2010-12-06 [PMID: 21132028] (Human)		Human
Vyth-Dreese FA, Sein J, van de Kasteele W, Dellemijn TA, van den Bogaard C, Nooijen WJ, de Gast GC, Haanen JB, Bex A Lack of anti-tumour reactivity despite enhanced numbers of circulating natural killer T cells in two patients with metastatic renal cell carcinoma. Clin. Exp. Immunol., 2010-10-05;162(3):447-59. 2010-10-05 [PMID: 20942806] (Human)		Human
Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, DerSimonian R, Greenwald JH, Roby G, Mican J, Sher A, Roederer M, Sereti I Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood, 2010-07-26;116(19):3818-27. 2010-07-26 [PMID: 20660788] (Human)		Human
Sugalski JM, Rodriguez B, Moir S Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection. J. Immunol., 2010-07-23;185(5):3019-27. 2010-07-23 [PMID: 20656924] (Human)		Human
Thiant S, Yakoub-Agha I, Magro L, Trauet J, Coiteux V, Jouet JP, Dessaint JP, Labalette M Plasma levels of IL-7 and IL-15 in the first month after myeloablative BMT are predictive biomarkers of both acute GVHD and relapse. Bone Marrow Transplant., 2010-03-01;45(10):1546-52. 2010-03-01 [PMID: 20190846] (Human)		Human
Juffroy O, Bugault F, Lambotte O, Landires I, Viard JP, Niel L, Fontanet A, Delfraissy JF, Theze J, Chakrabarti LA Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J. Virol., 2010-01-01;84(1):96-108. 2010-01-01 [PMID: 19864382] (Human)		Human
Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J. Immunol., 2009-06-15;182(12):7389-97. 2009-06-15 [PMID: 19494261] (Human)		Human
Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma. Int. J. Cancer, 2009-09-01;125(5):1092-101. 2009-09-01 [PMID: 19391137] (Human)		Human
Rihl M, Kellner H, Kellner W, Barthel C, Yu DT, Tak PP, Zeidler H, Baeten D Identification of interleukin-7 as a candidate disease mediator in spondylarthritis. Arthritis Rheum., 2008-11-01;58(11):3430-5. 2008-11-01 [PMID: 18975340] (Human)		Human
Louis CU, Straathof K, Bollard CM, Gerken C, Huls MH, Gresik MV, Wu MF, Weiss HL, Gee AP, Brenner MK, Rooney CM, Heslop HE, Gottschalk S Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients. Blood, 2008-10-29;113(11):2442-50. 2008-10-29 [PMID: 18971421] (Human)		Human
Mancebo E, Clemente J, Sanchez J, Ruiz-Contreras J, De Pablos P, Cortezon S, Romo E, Paz-Artal E, Allende LM Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery. Clin. Exp. Immunol., 2008-09-22;154(3):375-83. 2008-09-22 [PMID: 18811694] (Human)		Human
Benedict C, Dimitrov S, Marshall L, Born J Sleep enhances serum interleukin-7 concentrations in humans. Brain Behav. Immun., 2007-05-23;21(8):1058-62. 2007-05-23 [PMID: 17524612] (Human)		Human
Fluur C, De Milito A, Fry TJ, Vivar N, Eidsmo L, Atlas A, Federici C, Matarrese P, Logozzi M, Rajnavolgyi E, Mackall CL, Fais S, Chiodi F, Rethi B Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection. J. Immunol., 2007-04-15;178(8):5340-50. 2007-04-15 [PMID: 17404319] (Human)		Human
Colucci S, Brunetti G, Cantatore FP, Oranger A, Mori G, Quarta L, Cirulli N, Mancini L, Corrado A, Grassi FR, Grano M Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis. J. Pathol., 2007-05-01;212(1):47-55. 2007-05-01 [PMID: 17370327] (Human)		Human
Koesters SA, Alimonti JB, Wachihi C, Matu L, Anzala O, Kimani J, Embree JE, Plummer FA, Fowke KR IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation. Eur. J. Immunol., 2006-02-01;36(2):336-44. 2006-02-01 [PMID: 16421946] (Human)		Human
Johnson SE, Shah N, Panoskaltsis-Mortari A, Lebien TW Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells. J. Immunol., 2005-12-01;175(11):7325-31. 2005-12-01 [PMID: 16301638] (Human)		Human
Muthukumar A, Wozniakowski A, Gauduin MC, Paiardini M, McClure HM, Johnson RP, Silvestri G, Sodora DL Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression. Blood, 2003-10-02;103(3):973-9. 2003-10-02 [PMID: 14525780] (Primate - Cebus capucinus (White-headed Capuchin Monkey), Primate - Macaca mulatta (Rhesus Macaque))		Primate - Cebus capucinus (White-headed Capuchin Monkey), Primate - Macaca mulatta (Rhesus Macaque)
Storek J, Gillespy T, Lu H, Joseph A, Dawson MA, Gough M, Morris J, Hackman RC, Horn PA, Sale GE, Andrews RG, Maloney DG, Kiem HP Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys. Blood, 2003-01-23;101(10):4209-18. 2003-01-23 [PMID: 12543864] (Primate - Papio cynocephalus (Yellow Baboon))		Primate - Papio cynocephalus (Yellow Baboon)
Show All 45 Publications. Collapse Publications.

Array HS750

• IL-7 Antibodies
• IL-7 Antibody Pair
• IL-7 ELISA Kit
• IL-7 Lysate
• IL-7 Proteins
• IL-7 ELISAs
• IL-7 Proteins and Enzymes